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Best Vitamin B6 Supplements

10 Best Vitamin B6 Supplements – Ranked & Reviewed for 2018

If you’re looking for the best vitamin B6 supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Vitamin B6 Supplements Guide.

Top 10 Vitamin B6 Supplements

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#1Natures Way Vitamin B6 SNature’s Way Vitamin B6More Info
#2Nature Made Vitamin B6 SNature Made Vitamin B6More Info
#3Now Foods Vitamin B6 SNOW Foods Vitamin B6More Info
#4Natures Bounty Vitamin B6 SNature’s Bounty Vitamin B6More Info
#5Bulk Supplements Pure Vitamin B6 SBulk Supplements Pure Vitamin B6More Info
#6Life Extension Vitamin B6 SLife Extension Vitamin B6More Info
#7Solgar Vitamin B6 SSolgar Vitamin B6More Info
#8Source Naturals Vitamin B6 SSource Naturals Vitamin B6More Info
#9Bluebonnet Vitamin B 6 SBlueBonnet Vitamin B-6More Info
#10Solaray Vitamin B6 SSolaray Vitamin B-6More Info

Vitamin B6 Supplements Guide

What is Vitamin B6?

Vitamin B6 is a water-soluble member of the B-complex vitamin family. It’s made of the components pyridoxine, pyridoxine and pyridoximine. The type most used in supplements is pyridoxine.

Like the other B vitamins, vitamin B6 works best in the presence of other B vitamins. For example, B6 needs to be present for the body to absorb B12. It helps the body produce the hydrochloric acid in the stomach that’s necessary for digestion and supports the functioning of lineolic acid. Pyridoxine is a coenzyme that helps the body break down and use fats, proteins and carbohydrates, and it is necessary for the body to make red blood cells and antibodies.

Vitamin B6 allows the liver and muscles to release their stores of glycogen for energy and helps convert the amino acid tryptophan into niacin. Vitamin B6 helps the body synthesize both DNA and RNA and makes sure they function properly. It is good for a healthy immune system.

The balance of sodium and potassium is mediated by the presence of vitamin B6. This balance controls bodily fluids and the functioning of the muscles and nerves.

The best sources of vitamin B6 are animal proteins such as chicken, turkey, shrimp, salmon and dairy products. Beef liver is especially rich in the vitamin. Because of this, vegetarians and vegans would benefit from vitamin B6 supplements. People who are fasting or on a diet also benefit from vitamin B6 supplementation, as do pregnant or nursing women, people undergoing radiation therapy, heart patients, older people and women who use oral contraceptives.

Alcoholics or heavy drinkers, people with autoimmune diseases such as lupus or rheumatoid arthritis, and people with renal disease often have trouble absorbing vitamin B6. Patients who have undergone bariatric, or weight loss surgery need supplemental vitamin B6 as well as supplementation of other nutrients, especially if they’ve had bypass surgery.

People who are deficient in vitamin B6 often suffer from hypoglycemia and are especially sensitive to insulin. Other symptoms are hair loss, edema during pregnancy, cracks that appear around the eyes and mouth, arm and leg cramps and numbness and nerve pain.

Arthritis, frequent urination, temporary paralysis of an arm or leg, some types of anemia, irritability, depression, anxiety and problems with short term memory are also some other signs of potential B6 deficiency.

The amount of B6 a person needs depends on their age, sex and physical condition. The usual amount needed by newborns and babies up to six months old is 0.1 milligrams and gradually rises throughout childhood. Adults age 19 to 50 need 1.3 mg, though men aged 51 and older need more B6 than do women. The people who need the highest levels of vitamin B6 are pregnant and nursing teenagers and women. The upper limit for babies hasn’t been established, but it ranges from 30 mg for children one to three years old to 100 mg for adults.



People can take fairly large doses of vitamin B6 without ill effects, since it is excreted from the body. However, some people experience nausea and vomiting, stomach pains, tingling in their appendages, headache, painful skin lesions, photosensitivity and sleepiness. People who take very high doses for a long period of time can suffer nerve damage. This might manifest as:

  • Decreased sensitivity to temperature
  • Decreased sensitivity to touch
  • Numbness around the mouth

High doses that are given to newborn babies can lead to seizures. Symptoms stop when the vitamin is discontinued, and the person should recover completely within half a year or so.

Like many other vitamins and supplements, vitamin B6 can interact with other drugs the patient is taking. When it’s taken with cycloserine it can exacerbate the nerve damage that can be caused by the drug. Seizure medications can lower the effectiveness of both the vitamin and the drug, and taking vitamin B6 with theophylline, which is taken to treat asthma, can lead to seizures.

Other medications to be careful of when taking vitamin B6 supplements are hydralazine, used to treat hypertension and penicillamine, which is used for rheumatoid arthritis. The effectiveness of tetracycline is reduced when taking B6 or any of the other B complex vitamins, though the effect of tricyclic antidepressants may be enhanced. On the other hand, the vitamin may reduce blood levels of MAOI antidepressants.

Always speak with a medical professional or doctor before taking any supplements.

Taking Vitamin B6 Supplements

Vitamin B6 can be taken in a multivitamin or it can be taken by itself. Supplements come in drops or chewable form for children, tablets, lozenges and soft gels. Sometimes the vitamin is injected, and this should be done by a health professional. A person should check with their doctor or their child’s pediatrician to learn whether they or their child need vitamin B6 supplements.

When taking the supplement, the patient should follow the directions on the label and not take larger or smaller doses than those recommended. Don’t take extra supplements if a dose is missed.

What to Look for in a Good Vitamin B6 Supplement

The fact is the FDA does not regulate dietary supplements as stringently as they might, so it’s up to the buyer to do a bit of homework when it comes to finding a good vitamin B supplement.

If the buyer is not being prescribed vitamin B6 supplements and is looking to buy some over the counter, they need to consult with their physician and do some research on their own. The internet is an excellent place to start, as are stores that specialize in health foods. The people who work in these stores should be able to answer questions about vitamin B6 supplementation. The NIH’s Dietary Supplement Label Database is a good resource, as are the lists of recalls and warnings from the FDA. Any bottle of vitamin B6 should have the name and address of the manufacturer clearly printed on the label. The buyer shouldn’t hesitate to contact the manufacturer and ask questions, especially about their quality control protocols.

The label on the supplement should bear the seal of NSF International or US Pharmacopeia, which inspect, test and certify products related to health and safety. It’s a good practice to read online reviews from customers who have bought the same product.

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