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Best Sam E Supplements

10 Best SAM-e Supplements – Reviewed & Ranked for 2018

If you’re looking for the best SAM-e supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our SAM-e Supplements Guide.

Top 10 SAM-e Supplements

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#1Doctor's Best Sam E 400 SDoctor’s Best SAM-e 400More Info
#2Nature Made Sam E Complete SNature Made SAM-e CompleteMore Info
#3Now Foods Sam E SNow Foods SAM-eMore Info
#4Jarrow Formulas Sam E SJarrow Formulas SAM-eMore Info
#5Source Naturals Double Strength Same SSource Naturals Double Strength SAM-eMore Info
#6Natrol Same SNatrol SAM-eMore Info
#7Pure Encapsulations – Same SPure Encapsulations – SAM-eMore Info
#8We Like Vitamins Best Value Sam E SWe Like Vitamins Best Value SAM-eMore Info
#9Mental Refreshment Nutrition Sam E SMental Refreshment Nutrition SAM-eMore Info
#10Piping Rock Health Products Same SPiping Rock Health Products SAM-eMore Info

SAM-e Supplements Guide

Since 1999, many Americans have tried using a supplement commonly known by its acronym, SAMe. It was introduced as a prescription drug in Italy in 1979 and made the circuit through Europe before coming to America just before the end of the twentieth century.

While more high-quality scientific studies are required in order to more fully comprehend what SAMe does and how it might benefit or harm certain people, it appears to be relatively safe for many people to take.

As always, a doctor should be consulted before a new supplement is added to a dietary and medication regimen. SAMe does seem to negatively interact with some medications, including MAOI antidepressants.

What is SAMe?

S-Adenosyl-L-Methionine (also referred to by the acronym SAMe) is a synthetic form of the naturally-occurring chemical found in the human body as a result of the amino acid methionine interacting with an energy-carrying molecule called adenosine triphosphate. Additionally, methionine is found in certain foods, such as cheese, pork, and fish.

Depression and impaired liver functions are reported in those with abnormal levels of methionine made naturally in their bodies.

SAMe works by donating a methyl group during a chemical reaction, which causes it to be converted to the amino acid S-adenosyl-L-homocysteine (SAH), which is used in metabolic pathways and as an intermediary in the synthesis of adenosine and cysteine.



First and foremost, it is imperative that anyone interested in taking a supplement speaks with their doctor to find out if it is the right supplement for them and, if so, what dosage they should take.

There is concern that it might worsen symptoms of mania in those with bipolar disorder. Those with bipolar disorder are usually encouraged to not take SAMe due to these negative side-effects. SAMe supplements are also seemingly unsafe for those diagnosed with the rare genetic disorder Lesch-Nyhan syndrome (which is caused by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) enzyme deficiency), as it might make some of the syndrome’s symptoms even worse. Additionally, since SAMe supplements seem to impact the Central Nervous System (CNS), it is advisable that anyone having surgery stop taking SAMe supplements at least two weeks prior to their operation date.

Always speak with a medical professional or doctor before taking any supplements. Always read the product label for instructions and directions.

Taking SAMe Supplements

SAMe should always be taken prior to ingesting any food. Drinking water with SAMe is encouraged if symptoms like heartburn or nausea occur, and SAMe should be taken earlier in the day since it is a stimulant and can contribute to sleep disruption and even potentially insomnia if taken in the evening or at night.

SAMe is usually taken in daily dosages ranging between 400 mg on the low end and 1,600 mg on the high end. Lower dosages (which range from 400 to 800 mg) should ideally be taken once per day, about half an hour prior to a full meal. Anyone who plans on taking higher dosages should consider splitting them up, taking the first dosage half an hour before eating breakfast and taking the second dosage about half an hour before consuming their lunch.

SAMe may not be safe to take with antidepressants (specifically MAOIs) but might be okay to take with some SSRIs (like Zoloft, Paxil, and Prozac), and those who are taking other medications at the same time should consult with their doctor to see if it is safe to take those medications in conjunction with SAMe. SAMe that is marketed toward adult humans should only be taken by adult humans. Do not attempt to give SAMe to people under the age of 18 or to animals. (There are SAMe supplements specifically designed for pets.)

What to Look for in a Good SAMe Supplement

It is imperative that individuals looking into taking SAMe supplements know what to look for in a high-quality SAMe supplement. One of the most important things to look for is SAMe supplements that have an enteric coating. Enteric coating protects SAMe from stomach acid destruction as it passes through the small intestine and stomach. SAMe should be released after it passes through the stomach, but food blocks the absorption of SAMe, so make sure to take enteric coated SAMe prior to eating anything.

There are many brands of SAMe supplements available on the market, so it is important to be aware of which brands are more reputable and reliable with their products. Some brands use talc as one of their ingredients, and talc should ideally be avoided. Talc is a carcinogen containing asbestos fibers (asbestos can become lethal if it gets into the lungs, where it will incubate, causing a person to drown in their own lung fluid), and it is not considered food grade by the FDA. However, it is still present in many supplements.

Good SAMe supplements should also be soy-free. Soy (sometimes presented as soybean oil) is an allergen that causes negative side-effects like indigestion. Also, 90% of soy products grown in the United States are sprayed with a deadly herbicide called Roundup and tend to be genetically-modified since they are mass-produced in order to be affordably priced.

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