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Best Pyruvate Supplements

10 Best Pyruvate Supplements for 2020

If you’re looking for the best pyruvate supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Pyruvate Supplements Guide.

Top 10 Pyruvate Supplements

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#1Now Sports Pyruvate SNOW Sports PyruvateGet it on Amazon
#2Pure Naturals Calcium Pyruvate SPure Naturals Calcium PyruvateGet it on Amazon
#3Genetic Solutions Calcium Pyruvate SGenetic Solutions Calcium PyruvateGet it on Amazon
#4All Nature Pharmaceuticals Calcium Pyruvate SAll Nature Pharmaceuticals Calcium PyruvateGet it on Amazon
#5Piping Rock Health Products Calcium Pyruvate SmallPiping Rock Health Products Calcium PyruvateGet it on Amazon
#6Purecontrol Supplements Calcium Pyruvate SPureControl Supplements Calcium PyruvateGet it on Amazon
#7Solaray Calcium Pyruvate SSolaray Calcium PyruvateGet it on Amazon
#8Earth Natural Supplements Calcium Pyruvate SEarth Natural Supplements Calcium PyruvateGet it on Amazon
#9Biopower Calcium Pyruvate SBioPower Calcium PyruvateGet it on Amazon
#10Swanson Triple Pyruvate Electrolyte Complex SSwanson Triple Pyruvate Electrolyte ComplexGet it on Amazon

Pyruvate Supplements Guide

Pyruvate, which is derived from pyruvic acid, is a compound made naturally by the body when it breaks down sugar (a process called glycolysis). Apples, cheese, dark beers, and red wine all naturally contain pyruvate. In the form of a dietary supplement, pyruvate is often claimed to be an aid to weight loss and increase exercise endurance and/or athletic performance.

A nationally televised program in the United States has even featured an M.D. claiming that weight loss results can be achieved by taking six grams per day of a pyruvate supplement for eight weeks. The scientific research paints a much different picture, though.

What is Pyruvate?

Pyruvate could appear on the label of a supplement under several different names, including the following:

  • 2-Oxopropanoic acid
  • Acetylformic Acid
  • Calcium Pyruvate
  • Creatine Pyruvate
  • Magnesium Pyruvate
  • Potassium Pyruvate
  • Proacemic Acid
  • Pyruvic Acid
  • Sodium Pyruvate

Minerals such as calcium, magnesium, potassium, and sodium are added to pyruvate supplements to help stabilize the active ingredient, giving these supplements a longer shelf life. Some marketers of supplements have claimed that pyruvate, taken orally, acts as an antioxidant in the body, but this claim is not validated by the chemistry of pyruvate supplements.


Possible side effects of pyruvate supplements include bloating, diarrhea, gas, stomach upset, and decreased levels of high-density lipoproteins (HDL, or “good” cholesterol). Those with irritable bowel syndrome (IBS) should be wary of taking pyruvate supplements, since the supplements may worsen the symptoms. Some gastric side effects were most likely to occur when the subject took large doses (100 grams) of pyruvate supplements and are less common in those taking standard doses (5-10 grams daily).

One documented case has been reported of a child who died after being treated with intravenous (IV) pyruvate supplements. It is not known if this was an isolated incident; more research is needed on the safety of pyruvate subjects in children. The effects of long-term use of calcium pyruvate supplements on the heart, kidneys, and liver are unknown, so people with known conditions of these organs should consult with a health care professional before starting to use pyruvate supplements.

It has not yet been conclusively shown that pyruvate supplements are safe for those who are pregnant or breast feeding. People with these conditions should wait to use pyruvate supplements until more conclusive date showing these supplements are safe become available.

Always speak with a medical professional or doctor before taking any supplements. Always read the product label for instructions and directions.

Taking Pyruvate Supplements

As a dietary supplement, the most common form of pyruvate available in commercial preparations is calcium pyruvate. As a general rule, the user should not take more the dosage recommended by the manufacturer. Many commercial pyruvate supplements are available in capsules of between 500 and 1,000 mg.

Supplements containing calcium pyruvate may be preferable to those containing sodium pyruvate as the active ingredient. The sodium used to stabilize the pyruvate can raise the level of sodium in the body, which could be an issue for those who need to restrict sodium from their diets, such as people with high blood pressure and people with kidney disease. Individuals with kidney disease must also be careful with the other minerals contained in pyruvate supplements. Sodium pyruvate supplements may raise blood pressure to unsafe levels in people who already have high blood pressure.

The maximum daily recommended dosage of calcium is 2.5 grams per day. People who take a calcium pyruvate supplement should not exceed this dosage. High dosages of calcium can have serious health consequences that include confusion, coma, delirium, and death. To be safe, individuals should consult with a health care provider before beginning to use any pyruvate supplement.

What to Look for in a Good Pyruvate Supplement

The U.S. Food and Drug Administration (FDA) does not inspect dietary supplements to make sure they are free from chemical contaminants and other contaminants such as metals. For this reason, consumers should be sure to buy supplements that come from reputable manufacturers with a good record of making safe, uncontaminated products.

To help them find products with good safety records, consumers can look for the seal of approval of one or more of the following third-party organizations:, NSF International, and U.S. Pharmacopeia (USP). Because pyruvate supplements are relatively expensive, consumers must be careful to select quality supplements to help ensure they are truly getting what they pay for.


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