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Best Pyruvate Supplements

10 Best Pyruvate Supplements – Reviewed & Ranked for 2017

If you’re looking for the best pyruvate supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Pyruvate Supplements Guide.

Top 10 Pyruvate Supplements

#1 Now Sports Pyruvate S NOW Sports Pyruvate More Info
#2 Pure Naturals Calcium Pyruvate S Pure Naturals Calcium Pyruvate More Info
#3 Genetic Solutions Calcium Pyruvate S Genetic Solutions Calcium Pyruvate More Info
#4 All Nature Pharmaceuticals Calcium Pyruvate S All Nature Pharmaceuticals Calcium Pyruvate More Info
#5 Piping Rock Health Products Calcium Pyruvate Small Piping Rock Health Products Calcium Pyruvate More Info
#6 Purecontrol Supplements Calcium Pyruvate S PureControl Supplements Calcium Pyruvate More Info
#7 Solaray Calcium Pyruvate S Solaray Calcium Pyruvate More Info
#8 Earth Natural Supplements Calcium Pyruvate S Earth Natural Supplements Calcium Pyruvate More Info
#9 Biopower Calcium Pyruvate S BioPower Calcium Pyruvate More Info
#10 Swanson Triple Pyruvate Electrolyte Complex S Swanson Triple Pyruvate Electrolyte Complex More Info

Pyruvate Supplements Guide

Pyruvate, which is derived from pyruvic acid, is a compound made naturally by the body when it breaks down sugar (a process called glycolysis). Apples, cheese, dark beers, and red wine all naturally contain pyruvate. In the form of a dietary supplement, pyruvate is often claimed to be an aid to weight loss and increase exercise endurance and/or athletic performance.

A nationally televised program in the United States has even featured an M.D. claiming that weight loss results can be achieved by taking six grams per day of a pyruvate supplement for eight weeks. The scientific research paints a much different picture, though.

What is Pyruvate?

According to some claims, pyruvate supplements are said to be useful for treating cataracts, cancer, and high cholesterol as well as obesity. However, not all of these effects are supported by scientific evidence.

Pyruvate could appear on the label of a supplement under several different names, including the following:

  • 2-Oxopropanoic acid
  • Acetylformic Acid
  • Calcium Pyruvate
  • Creatine Pyruvate
  • Magnesium Pyruvate
  • Potassium Pyruvate
  • Proacemic Acid
  • Pyruvic Acid
  • Sodium Pyruvate

Minerals such as calcium, magnesium, potassium, and sodium are added to pyruvate supplements to help stabilize the active ingredient, giving these supplements a longer shelf life. Some marketers of supplements have claimed that pyruvate, taken orally, acts as an antioxidant in the body, but this claim is not validated by the chemistry of pyruvate supplements.

Benefits of Pyruvate Supplements

According to some reports, pyruvate supplements have a small effect on reducing weight and reducing body fat. In one study, overweight study participants took 6 grams of pyruvate supplements or a placebo per day, along with adhering to a 2,000 calorie diet and 45 to 60 minutes of exercise, for six weeks. Those who took the pyruvate supplements showed a significant reduction in body weight, while those who took the placebo did not.

It should be noted that these studies were conducted on individuals who were confined to a research ward under very specific conditions for the duration of the study. The findings of the study do not necessarily translate to the living conditions of pyruvate users in the “real world.” Furthermore, although the amounts of weight lost in the study were considered to be clinically significant, they were relatively small amounts of weight in the more general sense.

Early reports have shown that sodium pyruvate, administered by IV for 25 days, may help improve the liver functioning of people whose livers have been damaged due to alcohol overuse. This study is preliminary, and more research needs to be done in this area. Intravenous use of pyruvate supplements should only be done under the observation of health care professionals and is not something that is recommended for consumers who wish to try pyruvate supplements at home.

Similarly, some preliminary reports have shown improvement in the symptoms of chronic obstructive pulmonary disorder (COPD) by individuals taking pyruvate supplements in the form of a nebulizer. The study used sodium pyruvate and a 6-week trial period. Further study is needed, and this method is only for use under the supervision of a health care professional.

Hearth Health

Another possible medical application of pyruvate is being investigated in the treatment of congestive heart failure. Doctors injected a pyruvate solution into an artery that flows into the heart of patients with congestive heart failure, and some patients experienced relief of some of their symptoms. As with intravenous use of pyruvate supplements, this use should only be performed by qualified medical professionals and should not be attempted by consumers using pyruvate supplements at home. Similar research has shown that pyruvate solution may be useful during coronary artery bypass graft (CABG) surgery.

The liquid form, pyruvic acid, is sometimes used topically in “facial peels” designed to reduce the appearance of wrinkles and other signs of aging on the skin. Commercial skin care preparations containing pyruvic acid as an ingredient have also been shown to aid in the treatment of the flaky, scaly skin condition known as ichthyosis.

Pyruvic acid in skin care products does seem to be effective in encouraging the top layers of skin cells to slough off, exposing newer skin underneath. In this way, it does seem to reverse the appearance of some of the damage caused by exposing skin to sunlight. Using pyruvic acid on the skin for up to four weeks does seem to decrease the appearance of wrinkles.

Are There any Side Effects?

Because pyruvate is made naturally by the human body, users of pyruvate supplements are unlikely to overdose on them. Possible side effects of pyruvate supplements include bloating, diarrhea, gas, stomach upset, and decreased levels of high-density lipoproteins (HDL, or “good” cholesterol). Those with irritable bowel syndrome (IBS) should be wary of taking pyruvate supplements, since the supplements may worsen the symptoms. Some gastric side effects were most likely to occur when the subject took large doses (100 grams) of pyruvate supplements and are less common in those taking standard doses (5-10 grams daily).

One documented case has been reported of a child who died after being treated with intravenous (IV) pyruvate supplements. It is not known if this was an isolated incident; more research is needed on the safety of pyruvate subjects in children. The effects of long-term use of calcium pyruvate supplements on the heart, kidneys, and liver are unknown, so people with known conditions of these organs should consult with a health care professional before starting to use pyruvate supplements.

It has not yet been conclusively shown that pyruvate supplements are safe for those who are pregnant or breast feeding. People with these conditions should wait to use pyruvate supplements until more conclusive date showing these supplements are safe become available.

How to Take Pyruvate Supplements

As a dietary supplement, the most common form of pyruvate available in commercial preparations is calcium pyruvate. As a general rule, the user should not take more the dosage recommended by the manufacturer. Many commercial pyruvate supplements are available in capsules of between 500 and 1,000 mg. For those using topical pyruvic acid for skin aging treatment, a safe ratio of pyruvic acid is thought to be 50%.

Supplements containing calcium pyruvate may be preferable to those containing sodium pyruvate as the active ingredient. The sodium used to stabilize the pyruvate can raise the level of sodium in the body, which could be an issue for those who need to restrict sodium from their diets, such as people with high blood pressure and people with kidney disease. Individuals with kidney disease must also be careful with the other minerals contained in pyruvate supplements. Sodium pyruvate supplements may raise blood pressure to unsafe levels in people who already have high blood pressure.

The maximum daily recommended dosage of calcium is 2.5 grams per day. People who take a calcium pyruvate supplement should not exceed this dosage. High dosages of calcium can have serious health consequences that include confusion, coma, delirium, and death. To be safe, individuals should consult with a health care provider before beginning to use any pyruvate supplement.

What to Look for in a Good Pyruvate Supplement

The U.S. Food and Drug Administration (FDA) does not inspect dietary supplements to make sure they are free from chemical contaminants and other contaminants such as metals. For this reason, consumers should be sure to buy supplements that come from reputable manufacturers with a good record of making safe, uncontaminated products.

To help them find products with good safety records, consumers can look for the seal of approval of one or more of the following third-party organizations: ConsumerLabs.com, NSF International, and U.S. Pharmacopeia (USP). Because pyruvate supplements are relatively expensive, consumers must be careful to select quality supplements to help ensure they are truly getting what they pay for.


Note: Always speak with your doctor before taking any supplements featured on this website. This article has not been written, reviewed or endorsed by a medical professional and may not be used to diagnose or treat any medical conditions.