Home / Memory & Focus / 10 Best Phosphatidylserine Supplements for 2019

Please Note: We are compensated if you buy anything through the links in this article. For more info, read our disclosure page.

Best Phosphatidylserine Supplements

10 Best Phosphatidylserine Supplements for 2019

If you’re looking for the best phosphatidylserine supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Phosphatidylserine Supplements Guide.

Top 10 Phosphatidylserine (PS) Supplements

If you buy anything using the links below, we get a commission.

#1Swanson Triple Strength Phosphatidylserine SSwanson Triple-Strength PhosphatidylserineGet it on Amazon
#2Jarrow Formulas Ps 100 SJarrow Formulas Ps-100Get it on Amazon
#3Now Foods Soy Free Phosphatidyl Serine Tablets SNow Foods Soy-free Phosphatidyl SerineGet it on Amazon
#4Natural Factors Phosphatidylserine SNatural Factors PhosphatidylserineGet it on Amazon
#5Puritan's Pride Neuro Ps (phosphatidylserine) SPuritan’s Pride Neuro-PsGet it on Amazon
#6Mrm Ps 100 Mg SMRM PSGet it on Amazon
#7Life Extension Phosphatidylserine Vegetarian Capsules SLife Extension PhosphatidylserineGet it on Amazon
#8Thorne Research Iso Phos Phosphatidylserine Isolate SThorne Research – Iso-PhosGet it on Amazon
#9Pure Encapsulations Ps 100 (phosphatidylserine) SPure Encapsulations – PS 100Get it on Amazon
#10Designs For Health Ps 150 Phosphatidylserine SDesigns for Health – PS 150Get it on Amazon

Phosphatidylserine (PS) Supplements Guide

The market is increasingly appreciating phosphatidylserine (PS) supplements and their contribution to health. Unfortunately, people are not aware of its role in the human brain and body. For this reason, only a few people are keen on using these supplements. This compound is an amino acid that exists in the neural tissues. It protects the brain cells and transmits messages between them. Although phosphatidylserine occurs naturally, people use supplements to guarantee its adequacy.

The primary function of phosphatidylserine is acting like a gatekeeper to the brain. It allows nutrients, oxygen, and water. At the same time, it enables expulsion of metabolic wastes. The PS has a unique structure that enables its functions. The phospholipids are arranged in two layers. These layers are hydrophilic and hydrophobic simultaneously. It means they can attract water or repel it.

People can source phosphatidylserine from various protein-rich foods. The most abundant source is a brain of a cow, but it is not ingestible for humans. Its consumption can risk mad cow disease. Other edible sources include soybeans, cod, mackerel, egg yolk, beef liver, chicken or any other organ meat. While these foods are sources of PS, their quantities should be moderated. Large amounts may affect some people’s health in different ways.

What is Phosphatidylserine?

Phosphatidylserine (PS) is one of the basic building blocks of healthy cell membranes and brain tissue. Your body utilizes PS to build and maintain new brain tissue. PS interacts synergistically with EPA and DHA, omega-3 fatty acids most abundant in seafood.

PS works well with fatty acids because it is a phospholipid, an organic, fat-soluble compound that contains its own fatty acids or derivatives. In addition to fatty acids, PS also contains amino acids. Your brain typically contains the highest concentrations of PS in your body at any given time.

Although your body manufactures small mounts of PS naturally, you also obtain PS in small amounts from the foods you eat, such as:

  • Milk
  • Chicken leg, liver and breast
  • Beef, pork and veal
  • Anchovy
  • Unpolished rice
  • Whole grain barley
  • Trout, crayfish, Atlantic cod
  • Carrots
  • Potatoes

PS is a major component of soy lecithin, a food additive that helps to emulsify or lubricate ingredients, improve flavor and improve texture/mouthfeel in prepackaged foods like dry non-dairy creamer and dry cake mix. Lecithin occurs naturally in eggs, and the addition of soy lecithin mimics the smooth, silky texture and rich flavor that eggs impart.

Proposed Uses of PS

According to research, people are advised to consume supplements if they want to gain more benefits from these phospholipids. Among these benefits include inhibition of Alzheimer’s disease. This illness ranks the sixth place in causing the deaths of Americans. Alzheimer’s disease affects over five million people today. Phosphatidylserine controls the accumulation of amyloid beta, which causes the illness.

Another essential role of phosphatidylserine is the cognitive function. By transmitting messages from one brain cell to another, PS ensures that people maintain their cognitive abilities. Aging does not mean that the memory or brain function must deteriorate. This misconception ought to end.

The daily life entails numerous stressors that may overcome some people. Among these stressors are physical ones caused by exercise. While physical activity is healthy, overtraining triggers inflammation, muscle soreness, and other issues. Phosphatidylserine is vital for physically active people such as athletes and sports people.

Phosphatidylserine supplements have the presence of antioxidant properties. This feature is crucial in inhibiting oxidative damage, a common occurrence in the onset of dementia. Also, cell damage will not occur, which is a characteristic of dementia. The antioxidants fight free radicals that are likely to cause these damages or others.


Every beneficial thing is also likely to have a downside of it. Phosphatidylserine is not an exception of this observation. A specific dosage of these supplements may cause insomnia or stomach upsets.

Safety concerns about PS derived from bovine brain material persist. Bovine-sourced PS is rare to nonexistent on the market, so it isn’t the sort of concern you should bear in mind when shopping for PS supplements. Manufacturers generally disclose sources of PS in any product they offer.

However, the FDA does not require manufacturers to disclose risks of PS supplements. There are no unofficial or official reports of side effects, save the reactions of individuals allergic to soy who find themselves supplementing with soy-based PS or sunflower oil-based PS manufactured in a facility where machinery comes in contact with soy/other allergens.

Notwithstanding possible allergic reactions to soy, both soy and sunflower oil-based lecithin, are Generally Regarded as Safe (GRAS). GRAS is an official FDA designation attached to food additives. This designation effectively informs the public about the safety or harm of food additives, substances and chemicals.

Always speak with a medical professional or doctor before taking any supplements. Always read the product label for instructions and directions.

Taking Phosphatidylserine

Feel free to take the standard does to assess tolerance. The standard PS dose is 300 milligrams divided into three servings of 100 milligrams over the course of a day.

Since PS is fat-soluble, taking it in a fat/oil-based supplement form potentially increases its bioavailability. There is no definitive scientific evidence confirming that dry formulations and water-soluble versions are any less effective.

There are lifestyle benefits to granules and powdered PS supplements. They conveniently allow you to either fill your own capsules or customize blended homemade beverages. Feel free to add lecithin granules and powdered PS to smoothies, pre-workout shakes, post-workout shakes, liquid meal replacements and even diet shakes.

Considering the importance of phosphatidylserine, it does not receive sufficient awareness. People need to understand its essence and consider including it in their nutrition. Sources of PS may be several, but they do not have an adequate supply. Include supplements and guarantee a healthy and robust functioning mind. Young, middle-aged and older adults are fit to consume these supplements. A specialist will guide one on the right dosage to take daily.

What to Look For in a Good Phosphatidylserine Product

When appraising PS supplements, look for products whose labels fully disclose the dietary source of the PS in the supplement. Try to avoid bovine-sourced PS. Give preference to PS supplements that come highly endorsed by authorities and individuals respected within the medical and sports nutrition industries.

Check customer reviews on major e-commerce and sports nutrition websites.

Some PS supplements come in “complexes” or “stacks” containing other brain-boosters and nutrient co-factors. Complexes and stacks are neither more or less effective than PS alone.

Lastly, look for citations and certifications (like GMP) that confirm a manufacturer’s adherence to best practices and stringent quality assurance in the areas of sourcing raw materials, training staff, packaging and the transporting of its products.

Important Notice: The information on supplementhound.com is intended for entertainment purposes only and and does not constitute professional, medical or healthcare advice or diagnosis, and may not be used as such. The information on this site is not written, reviewed or endorsed by a medical professional, and is only to be used at your own risk. Make sure to follow label instructions for whichever product you purchase. Supplementhound.com does not assume liability for any actions undertaken after reading this information, and does not assume liability if one misuses products featured on this website. Always consult your doctor before using any products you see on this website. The results may vary about any product effectiveness.

About suppshound