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Best Phosphatidylserine Supplements

10 Best Phosphatidylserine Supplements – Ranked & Reviewed for 2018

If you’re looking for the best phosphatidylserine supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Phosphatidylserine Supplements Guide.

Top 10 Phosphatidylserine (PS) Supplements

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#1 Swanson Triple Strength Phosphatidylserine S Swanson Triple-Strength Phosphatidylserine More Info
#2 Jarrow Formulas Ps 100 S Jarrow Formulas Ps-100 More Info
#3 Now Foods Soy Free Phosphatidyl Serine Tablets S Now Foods Soy-free Phosphatidyl Serine More Info
#4 Natural Factors Phosphatidylserine S Natural Factors Phosphatidylserine More Info
#5 Puritan's Pride Neuro Ps (phosphatidylserine) S Puritan’s Pride Neuro-Ps More Info
#6 Mrm Ps 100 Mg S MRM PS More Info
#7 Life Extension Phosphatidylserine Vegetarian Capsules S Life Extension Phosphatidylserine More Info
#8 Thorne Research Iso Phos Phosphatidylserine Isolate S Thorne Research – Iso-Phos More Info
#9 Pure Encapsulations Ps 100 (phosphatidylserine) S Pure Encapsulations – PS 100 More Info
#10 Designs For Health Ps 150 Phosphatidylserine S Designs for Health – PS 150 More Info

Phosphatidylserine (PS) Supplements Guide

What is Phosphatidylserine?

Phosphatidylserine (PS) is one of the basic building blocks of healthy cell membranes and brain tissue. Your body utilizes PS to build and maintain new brain tissue. PS interacts synergistically with EPA and DHA, omega-3 fatty acids most abundant in seafood.

PS works well with fatty acids because it is a phospholipid, an organic, fat-soluble compound that contains its own fatty acids or derivatives. In addition to fatty acids, PS also contains amino acids. Your brain typically contains the highest concentrations of PS in your body at any given time.

Although your body manufactures small mounts of PS naturally, you also obtain PS in small amounts from the foods you eat, such as:

  • Milk
  • Chicken leg, liver and breast
  • Beef, pork and veal
  • Anchovy
  • Unpolished rice
  • Whole grain barley
  • Trout, crayfish, Atlantic cod
  • Carrots
  • Potatoes

PS is a major component of soy lecithin, a food additive that helps to emulsify or lubricate ingredients, improve flavor and improve texture/mouthfeel in prepackaged foods like dry non-dairy creamer and dry cake mix. Lecithin occurs naturally in eggs, and the addition of soy lecithin mimics the smooth, silky texture and rich flavor that eggs impart.




Safety concerns about PS derived from bovine brain material persist. Bovine-sourced PS is rare to nonexistent on the market, so it isn’t the sort of concern you should bear in mind when shopping for PS supplements. Manufacturers generally disclose sources of PS in any product they offer.

However, the FDA does not require manufacturers to disclose risks of PS supplements. There are no unofficial or official reports of side effects, save the reactions of individuals allergic to soy who find themselves supplementing with soy-based PS or sunflower oil-based PS manufactured in a facility where machinery comes in contact with soy/other allergens.

Notwithstanding possible allergic reactions to soy, both soy and sunflower oil-based lecithin, are Generally Regarded as Safe (GRAS). GRAS is an official FDA designation attached to food additives. This designation effectively informs the public about the safety or harm of food additives, substances and chemicals.

Always speak with a medical professional or doctor before taking any supplements. Always read the product label for instructions and directions.

Taking Phosphatidylserine

Feel free to take the standard does to assess tolerance. The standard PS dose is 300 milligrams divided into three servings of 100 milligrams over the course of a day.

Since PS is fat-soluble, taking it in a fat/oil-based supplement form potentially increases its bioavailability. There is no definitive scientific evidence confirming that dry formulations and water-soluble versions are any less effective.

There are lifestyle benefits to granules and powdered PS supplements. They conveniently allow you to either fill your own capsules or customize blended homemade beverages. Feel free to add lecithin granules and powdered PS to smoothies, pre-workout shakes, post-workout shakes, liquid meal replacements and even diet shakes.

What to Look For in a Good Phosphatidylserine Product

When appraising PS supplements, look for products whose labels fully disclose the dietary source of the PS in the supplement. Try to avoid bovine-sourced PS. Give preference to PS supplements that come highly endorsed by authorities and individuals respected within the medical and sports nutrition industries.

Check customer reviews on major e-commerce and sports nutrition websites.

Some PS supplements come in “complexes” or “stacks” containing other brain-boosters and nutrient co-factors. Complexes and stacks are neither more or less effective than PS alone.

Lastly, look for citations and certifications (like GMP) that confirm a manufacturer’s adherence to best practices and stringent quality assurance in the areas of sourcing raw materials, training staff, packaging and the transporting of its products.

Note: Always speak with your doctor before taking any supplements featured on this website. This article has not been written, reviewed or endorsed by a medical professional and may not be used to diagnose or treat any medical conditions. Supplementhound.com does not assume liability for any actions undertaken after reading this website, and does not assume liability if one misuses supplements that appear on this website. Always read and follow instructions on the product label.