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Best Nitric Oxide Supplements – Handy Guide and Top 10 Products for 2017

Nitric Oxide Supplement Guide & Rankings

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One of the most popular types of bodybuilding supplements on the market these days are nitric oxide products. Sometimes referred to as pre-workout supplements, but there is a slight difference since you can buy supplements that are specifically for pre-workout and supplements that are specifically for nitric oxide.

The benefit of the pump and increasing blood flow is well documented, so using supplements that help to promote this can definitely help to take your training progress to new heights. Supplementing before a workout can help you mainain your energy, increase strength and hit new strength and endurance peaks in your routine.

There are a number of different pump-enhancing supplements on the market but nitric oxide products tend to be the most well-known. Other varieties of pump-enhancing supplements include
Arginine and Citrulline Malate, so be sure to check out our top 10 lists for these products as well.

Today we are going to go into great detail by describing exactly what nitric oxide is, the benefits it may provide to you, how to best utilise it, and what to look for when purchasing a nitric oxide supplement.

Once you are well and truly in the know when it comes to nitric oxide supplements we are going to look at a list of the top 10 best nitric oxide supplements for 2017.

Using factors such as popularity, the quality of ingredients, feedback received from users, and value for money, we have compiled this top 10 list to make it easier than ever for you to figure out which nitric oxide supplement is the best for you.

See Also: Top 10 Pre-Workout Supplements

What is Nitric Oxide?

Nitric oxide is a molecule and free radical that occurs naturally within the human body.

Nitric oxide acts primarily as a signalling molecule, playing an integral role in a whole host of biological processes in the body, not least regulating the cardiovascular and circulatory system.

The human body is capable of synthesising nitric oxide from the amino acid L-Arginine, in combination with oxygen and numerous types of enzymes known as nitric oxide synthase enzymes or NOS.

Nitric oxide is used by the inner lining of the blood vessels in order to signal for surrounding muscles to relax, thereby causing a phenomenon known as vasodilation or dilation of the blood vessels. This result in a subsequent increase in blood flow.

Foods, and in particular vegetables, that are rich in nitrates can also increase nitric oxide concentrations in the body independent of the nitric oxide synthase enzyme pathway.

Beetroot, spinach, and other leafy greens[1] have been shown to increase levels of nitric oxide, providing cardioprotective benefits and even reducing blood pressure in individuals suffering from pre-hypertension.[2]

What are the Uses of Nitric Oxide?

Scientific research has demonstrated the role that nitric oxide plays in cardiovascular health and the circulatory system as a whole.

Nitric oxide is used in a variety of different medical contexts, including the treatment of primary pulmonary hypertension in neonatal patients[3]. It can also be used to reduce some of the pain associated with angina by dilating blood vessels and reducing arterial pressure, thereby reducing the demands being placed on the heart.[4]

Nevertheless, nitric oxide supplements are almost solely used in the context of athleticism and bodybuilding, with their primary purpose being to stimulate blood flow and increase the delivery of nutrients-rich blood and fluids to the muscles during training.

As we will see below when we look at the nitric oxide supplement rankings, these products typically utilise a combination of different ingredients to stimulate nitric oxide production through various pathways within the body.

The exact mechanisms of action through which these ingredients act can vary depending on the product you use, but their basic purpose remains the same.

See also: Top 10 Creatine Supplements

Who can Benefit From a Nitric Oxide Supplement, How, Why?

If you are interested in learning more about nitric oxide from a medical perspective then you would be best served referring to a medical textbook or speaking directly to your doctor or physician.

From the point of view of a bodybuilder or an avid weight lifter, we can quite clearly see how an increase in blood flow would be beneficial.

The vast majority of us will use nitric oxide supplements in combination with other products such as amino acids, creatine, and beta alanine, so anything that will stimulate the circulatory system will also enhance the delivery of these nutrients to the muscle tissues.

It is also worth mentioning that an increase in muscle pumps can also greatly help you to develop your mind-muscle connection.

The mind-muscle connection is absolutely vital in ensuring that you are optimally working the muscles you are trying to target with a given exercise, as opposed to simply going through the motions and using leverage and momentum, and offsetting much of the strain on to your joints and tendons.

What’s more, delivering a high volume of blood and other fluids to the muscles can cause additional damage to the muscle tissues, while also triggering a phenomenon known as cell swelling.

Cell swelling plays a direct role in the triggering of anabolic signalling within the body, as evidenced by these studies:

  1. http://suppversity.blogspot.in/2014/01/cell-swelling-keeps-muscles-pumped-for.html
  2. Haussinger D, Hallbrucker C, vom DS, Lang F, Gerok W. Cell swelling inhibits proteolysis in perfused rat liver. Biochem J 1990;272:239-42.
  3. Haussinger D, Hallbrucker C, vom DS, Decker S, Schweizer U, Lang F, et al. Cell volume is a major determinant of proteolysis control in liver. FEBS Lett 1991;283:70-2.

So we can clearly see that far from being purely cosmetic, increasing your pumps and vascularity does actually have a direct benefit in terms of stimulating muscle hypertrophy and helping you to make more rapid progress in the gym.

See also: Top 10 Intra-Workout Supplements

How and When Should You Take a Nitric Oxide Supplement?

Always follow the usage guidelines provided by the manufacturer on any supplement you purchase.

Because of its vasodilatory effects nitric oxide should be avoided by anyone who has ever suffered a heart attack or other form of cardiovascular disease.

Nitric oxide is a free radical that, in excessive levels, can cause liver damage. But this reason we strongly urge you to exercise caution prior to using a nitric oxide supplement if you have any prior or pre-existing liver conditions.

What’s more, nitric oxide should not be used by pregnant or breastfeeding women, nor should it be used by individuals under the age of 18.

Consult your doctor or physician prior to using nitric oxide if you have any pre-existing medical conditions or if you are currently using prescription medication.

Please note that these statements have been neither written nor reviewed by a doctor or medical authority of any kind.

See also: Top 10 Men’s Fat Burners

What to Look for in a Nitric Oxide Product

When looking into different nitric oxide supplements the best thing you can do is check to make sure that your product stimulate nitric oxide production via a number of different ingredients and pathways within the body.

Citrulline Malate and Arginine are two very common ingredients found in nitric oxide supplements that are well known for their benefits in this context.

In fact, these two ingredients have been found to be more effective in stimulating nitric oxide production then supplementation of actual exogenous nitric oxide itself.

Aside from this, the most important thing to think about is what experiences other people have had when using the supplements you are researching.

Couple of other things to look for:

  • Quality in production and manufacturing
  • Quantity and quulity of ingredients that are included
  • How easy the supplement is to use
  • Online user feedback and reviews
  • Value for price
  • Reputation and quality of company and brand

We have put together the following nitric oxide supplement rankings for this very reason; so that you can see which nitric oxide products have received the greatest amount of praise from athletes and bodybuilders who have used them.

So without further ado let’s take a look at this year’s list of the best nitric oxide supplements.

See also: Top 10 Women’s Fat Burners

10 Best Nitric Oxide Supplements on the Market Today

10.) MAN NOOPump



  • Contains a potent Multi-Pathway N.O. Stimulus blend
  • Provides thermogenic ingredients to stimulate metabolism
  • Also includes nootropic compounds to improve cognitive function and mental performance
  • Available in three fruity flavors
  • Available in packages containing 10 servings and 32 servings

As we just mentioned, stimulation of nitric oxide production through numerous pathways is the key to a quality nitric oxide supplement, which is why MAN NOOPump and its Multi-Pathway N.O. Stimulus blend is so effective.

MAN NOOPump combines nitric oxide stimulation with nootropic ingredients designed to enhance your mental clarity and improve your concentration at the gym, negating the need for excessive coffee consumption!

amazonlogo-150x42 OUT OF STOCK  Buy Now

9.) BSN N.O.-Xplode



  • Contains a blend of creatines and amino acids
  • Includes L-Citrulline Malate and other ingredients to stimulate nitric oxide production
  • Includes a range of thermogenic compounds to stimulate metabolism
  • Includes stimulants and nootropic compounds to improve mental performance
  • Available in six fruity flavors
  • Available in packages containing 30 servings and 60 servings
  • Also available in an alternative caffeine-free formula

BSN N.O.-Xplode is one of the most well-known nitric oxide supplements on the market, combining amino acids with creatine and stimulants to give you everything you need to unleash hell in the weights room.

If you are on the lookout for a nitric oxide product that has been tried and tested by countless bodybuilders around the world than you would definitely be well served to check out BSN N.O.-Xplode.

amazonlogo-150x42  $36.37  Buy Now




  • Provides 1 g of Creatine Nitrate and 1 g of Arginine AKG per serving
  • Contains 1.6 g of Beta Alanine per serving
  • Also provides B vitamins for enhanced neural function
  • Includes caffeine and amino acids to stimulate mental performance
  • Available in six fruity flavors
  • Available in packages containing 30 servings and 60 servings

CELLUCOR C4 EXTREME uses a special type of creatine known as Creatine Nitrate to boost your nitric oxide concentrations while also stimulating intra-cellular ATP production.

Kickass pre-workout supplements don’t get much better than CELLUCOR C4 EXTREME, making it well deserving of its spot in this year’s nitric oxide product list

amazonlogo-150x42  $28.49  Buy Now

7.) Controlled Labs White Flood



  • Contains Citrulline, Ornithine, and Carnitine Tartrate as part of a Nitric Flood Complex
  • includes Beta Alanine to enhance performance and improve endurance
  • Contains Caffeine, Huperzine A, and other cognitive boosters
  • Available in a delicious Juicy Watermelon flavor

Controlled Labs White Flood combines well-known nitric oxide-boosting ingredients with Beta Alanine and caffeine to get your motor running and keep you performing at your best every single workout.

If you want a nitric oxide supplement with a great taste then you are going to absolutely love the Watermelon flavor of Controlled Labs White Flood.

amazonlogo-150x42  $24.99  Buy Now




  • Made using a potent Vasoactive Arginase-Regulating NO Precursor Complex
  • Includes Citrulline Malate, Arginine, and other compounds to stimulate nitric oxide production
  • Contains Beta Alanine to improve endurance and performance in the gym
  • Includes a potent dose of Caffeine to promote mental clarity and focus
  • Available in packages containing 30 servings
  • Available in a delicious Pina Colada flavor

GAT NITRAFLEX uses GAT’s patented Vasoactive Arginase-Regulating NO Precursor Complex, which combines a number of proven ingredients to kick start nitric oxide synthesis.

With its nitric oxide blend, Caffeine, and Beta Alanine, you’re going to have no excuse for not making progress during your next training cycle when using GAT NITRAFLEX.

amazonlogo-150x42  $27.04  Buy Now

Top 5 Nitric Oxide Supplements

5.) BSN Nitrix 2.0



  • Contains a L-Citrulline to stimulate nitric oxide production
  • Includes potent antioxidants such as Grape Seed Extract and Trans-Resveratrol
  • Includes Black Pepper Extract to enhance nutrient absorption and stimulate blood flow
  • Also includes three different forms of Creatine as a Myogenic Matrix
  • Available in packages containing 90 tablets and 180 tablets

What we have here is another product by BSN that has been designed to stimulate nitric oxide production, this time with additional ingredients for enhanced efficacy.

BSN Nitrix 2.0 contains three forms of Creatine in addition to antioxidants and Black Pepper Extract, making for greater absorption and overall effectiveness.

amazonlogo-150x42  $38.97  Buy Now




  • Includes L-Citrulline and Arginine AKG to act as a precursor to nitric oxide production
  • Contains Beta Alanine to improve endurance and performance in the gym
  • Provides 120 mg of Caffeine and 50 mg of L-Theanine per serving
  • Provides 1 g of Creatine Monohydrate per serving
  • Includes Rhodiola Rosea Root to support hormonal function
  • Available in packages containing 50 servings

MUSCLETECH NEUROCORE covers multiple bases by enhancing pumps, stimulating the mind, and even helping to improve hormonal function with the inclusion of natural herbal extracts.

MUSCLETECH NEUROCORE combines a range of proven effective ingredients, leaving you with no more excuses for not making massive strides in your training.

amazonlogo-150x42  $18.97  Buy Now




  • Includes the potent ENGN Mind-to-Muscle Matrix Proprietary Blend
  • Contains Beta Alanine, Creatine Monohydrate, and other performance-enhancing substances
  • Also contains Caffeine Anhydrous and Huperzine A to stimulate cognitive function
  • Available in six superb flavors
  • Available in packages containing 8 and 30 servings
  • Also available as a Variety Pack containing 3 servings in 3 different flavors

EVLUTION NUTRITION ENGN and its ENGN Mind-to-Muscle Matrix Proprietary Blend is guaranteed to keep your engine humming through even the most grueling of workouts.

One thing that sets EVLUTION NUTRITION ENGN apart from the competition is that you can order the Variety Pack to try out three different flavors before making your final decision.

amazonlogo-150x42  $26.10  Buy Now

2.) Pro Supps NO3 DRIVE



  • Includes L-Citrulline and Agmatine Sulfate to stimulate nitric oxide production
  • Contains Ginseng and Astralagus Root for enhanced nutrient absorption
  • Also contains powerful antioxidants such as Resveratrol
  • Available in bottles containing 90 capsules for a total of 30 servings

Ginseng and Astralagus Root are combined with L-Citrulline and other nitric oxide boosters in Pro Supps NO3 DRIVE to create a synergistic hormonal cascade within your body.

With the added antioxidant protection that Pro Supps NO3 DRIVE offers you will be able to enjoy a little extra health insurance in addition to the obvious performance-enhancing benefits.

amazonlogo-150x42  $26.99  Buy Now

1.) Cellucor NO3 Chrome



  • Includes the highly effective Arginine Nitrate for unrivalled nitric oxide production
  • Also includes the Extreme Vascularity Complex
  • Includes the potent antioxidant Grape Seed Extract
  • Contains Nitrosigine and Citrulline Malate to act as nitric oxide precursors
  • Available in bottles containing 90 capsules and 180 capsules

Cellucor NO3 Chrome is an incredibly effective nitric oxide supplement that uses Arginine Nitrate as part of its Extreme Vascularity Complex to give you skin-splitting pumps every time you train.

With its range of nitric oxide precursors, antioxidants, and other performance-enhancing ingredients, Cellucor NO3 Chrome is easily the winner of this year’s Best Nitric Oxide Supplement Award.

amazonlogo-150x42  $49.99 (180 capsules)  Buy Now

Wrapping Up

So by now you should have more than information to easily figure out which nitric oxide supplement is going to be the best option for you.

As you can see there are a lot of different nitric oxide products on the market, some which incorporate additional ingredients like Creatine, Beta Alanine, and stimulants like Caffeine. If you are looking for a comprehensive pre-workout formula then this type of product definitely makes sense.

On the other hand, a more focused supplement might be your best bet if you’re purely looking for enhanced pumps.

Final Thoughts on The Best Nitric Oxide Supplements

Either way, we highly recommend using Cellucor NO3 Chrome as it has easily beaten out the competition to reign supreme as the best nitric oxide boosting supplement of 2017.

Link to this article: https://supplementhound.com/best-nitric-oxide-supplements/



[1] http://www.berkeleytest.com/plant-based.html
[2] https://www.ncbi.nlm.nih.gov/pubmed/18250365
[3] https://www.ncbi.nlm.nih.gov/pubmed/17375630
[4] https://www.ncbi.nlm.nih.gov/pubmed/8638524

Note: Always speak with your doctor before taking any supplements featured on this website. This article has not been written, reviewed or endorsed by a medical professional and may not be used to diagnose or treat any medical conditions.