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Best Nitric Oxide Supplements – Handy Guide and Top 10 Products for 2021

Nitric Oxide Rankings

One of the most popular types of bodybuilding supplements on the market these days are nitric oxide products. Sometimes referred to as pre-workout supplements, but there is a slight difference since you can buy supplements that are specifically for pre-workout and supplements that are specifically for nitric oxide.


See Also: Top 10 Pre-Workout Supplements

What is Nitric Oxide?

Nitric oxide is a molecule and free radical that occurs naturally within the human body.

Nitric oxide acts primarily as a signalling molecule, playing an integral role in a whole host of biological processes in the body, not least regulating the cardiovascular and circulatory system.

The human body is capable of synthesising nitric oxide from the amino acid L-Arginine, in combination with oxygen and numerous types of enzymes known as nitric oxide synthase enzymes or NOS.

Nitric oxide is used by the inner lining of the blood vessels in order to signal for surrounding muscles to relax, thereby causing a phenomenon known as vasodilation or dilation of the blood vessels. This result in a subsequent increase in blood flow.

Foods, and in particular vegetables, that are rich in nitrates can also increase nitric oxide concentrations in the body independent of the nitric oxide synthase enzyme pathway.

Beetroot, spinach, and other leafy greens[1] have been shown to increase levels of nitric oxide, providing cardioprotective benefits and even reducing blood pressure in individuals suffering from pre-hypertension.[2]


See also: Top 10 Creatine Supplements


See also: Top 10 Intra-Workout Supplements


See also: Top 10 Men’s Fat Burners

What to Look for in a Nitric Oxide Product

When looking into different nitric oxide supplements the best thing you can do is check to make sure that your product stimulate nitric oxide production via a number of different ingredients and pathways within the body.

Citrulline Malate and Arginine are two very common ingredients found in nitric oxide supplements that are well known for their benefits in this context.

In fact, these two ingredients have been found to be more effective in stimulating nitric oxide production then supplementation of actual exogenous nitric oxide itself.

Aside from this, the most important thing to think about is what experiences other people have had when using the supplements you are researching.

Couple of other things to look for:

  • Quality in production and manufacturing
  • Quantity and quulity of ingredients that are included
  • How easy the supplement is to use
  • Online user feedback and reviews
  • Value for price
  • Reputation and quality of company and brand

We have put together the following nitric oxide supplement rankings for this very reason; so that you can see which nitric oxide products have received the greatest amount of praise from athletes and bodybuilders who have used them.

So without further ado let’s take a look at this year’s list of the best nitric oxide supplements.

See also: Top 10 Women’s Fat Burners

Nitric Oxide Supplements Compared

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10.) MAN NOOPump



  • Contains a potent Multi-Pathway N.O. Stimulus blend
  • Provides thermogenic ingredients to stimulate metabolism
  • Also includes nootropic compounds
  • Available in three fruity flavors
  • Available in packages containing 10 servings and 32 servings

As we just mentioned, stimulation of nitric oxide production through numerous pathways is the key to a quality nitric oxide supplement, which is why MAN NOOPump and its Multi-Pathway N.O. Stimulus blend is so effective.

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9.) BSN N.O.-Xplode



  • Contains a blend of creatines and amino acids
  • Includes L-Citrulline Malate
  • Includes a range of thermogenic compounds
  • Includes stimulants and nootropic compounds
  • Available in six fruity flavors
  • Available in packages containing 30 servings and 60 servings
  • Also available in an alternative caffeine-free formula

BSN N.O.-Xplode is one of the most well-known nitric oxide supplements on the market, combining amino acids with creatine and stimulants to give you everything you need to unleash hell in the weights room.

If you are on the lookout for a nitric oxide product that has been tried and tested by countless bodybuilders around the world than you would definitely be well served to check out BSN N.O.-Xplode.

 $36.37  Check Current Price




  • Provides 1 g of Creatine Nitrate and 1 g of Arginine AKG per serving
  • Contains 1.6 g of Beta Alanine per serving
  • Also provides B vitamins
  • Includes caffeine and amino acids
  • Available in six fruity flavors
  • Available in packages containing 30 servings and 60 servings

CELLUCOR C4 EXTREME uses a special type of creatine known as Creatine Nitrate to boost your nitric oxide concentrations while also stimulating intra-cellular ATP production.

Kickass pre-workout supplements don’t get much better than CELLUCOR C4 EXTREME, making it well deserving of its spot in this year’s nitric oxide product list

 $28.49  Check Current Price

7.) Controlled Labs White Flood



  • Contains Citrulline, Ornithine, and Carnitine Tartrate as part of a Nitric Flood Complex
  • Includes Beta Alanine
  • Contains Caffeine and Huperzine A
  • Available in a delicious Juicy Watermelon flavor

Controlled Labs White Flood combines well-known nitric oxide-boosting ingredients with Beta Alanine and caffeine to get your motor running and keep you performing at your best every single workout.

If you want a nitric oxide supplement with a great taste then you are going to absolutely love the Watermelon flavor of Controlled Labs White Flood.

 $24.99  Check Current Price




  • Made using a potent Vasoactive Arginase-Regulating NO Precursor Complex
  • Includes Citrulline Malate, Arginine, and other compounds
  • Contains Beta Alanine
  • Includes a potent dose of Caffeine
  • Available in packages containing 30 servings
  • Available in a delicious Pina Colada flavor

GAT NITRAFLEX uses GAT’s patented Vasoactive Arginase-Regulating NO Precursor Complex, which combines a number of proven ingredients to kick start nitric oxide synthesis.

 $27.04  Check Current Price

5.) BSN Nitrix 2.0



  • Contains a L-Citrulline to stimulate nitric oxide production
  • Includes potent antioxidants such as Grape Seed Extract and Trans-Resveratrol
  • Includes Black Pepper Extract
  • Also includes three different forms of Creatine as a Myogenic Matrix
  • Available in packages containing 90 tablets and 180 tablets

What we have here is another product by BSN that has been designed to stimulate nitric oxide production, this time with additional ingredients for enhanced efficacy.

BSN Nitrix 2.0 contains three forms of Creatine in addition to antioxidants and Black Pepper Extract, making for greater absorption and overall effectiveness.

 $38.97  Check Current Price




  • Includes L-Citrulline and Arginine AKG to act as a precursor to nitric oxide production
  • Contains Beta Alanine
  • Provides 120 mg of Caffeine and 50 mg of L-Theanine per serving
  • Provides 1 g of Creatine Monohydrate per serving
  • Includes Rhodiola Rosea Root
  • Available in packages containing 50 servings

MUSCLETECH NEUROCORE combines a range of proven effective ingredients, leaving you with no more excuses for not making massive strides in your training.

 $18.97  Check Current Price




  • Includes the potent ENGN Mind-to-Muscle Matrix Proprietary Blend
  • Contains Beta Alanine, Creatine Monohydrate, and other performance-enhancing substances
  • Also contains Caffeine Anhydrous and Huperzine A
  • Available in six superb flavors
  • Available in packages containing 8 and 30 servings
  • Also available as a Variety Pack containing 3 servings in 3 different flavors

One thing that sets EVLUTION NUTRITION ENGN apart from the competition is that you can order the Variety Pack to try out three different flavors before making your final decision.

 $26.10  Check Current Price

2.) Pro Supps NO3 DRIVE



  • Includes L-Citrulline and Agmatine Sulfate to stimulate nitric oxide production
  • Contains Ginseng and Astralagus Root for enhanced nutrient absorption
  • Also contains powerful antioxidants such as Resveratrol
  • Available in bottles containing 90 capsules for a total of 30 servings

Ginseng and Astralagus Root are combined with L-Citrulline and other nitric oxide boosters in Pro Supps NO3 DRIVE to create a synergistic hormonal cascade within your body.

 $26.99  Check Current Price

1.) Cellucor NO3 Chrome



  • Includes the highly effective Arginine Nitrate for unrivalled nitric oxide production
  • Also includes the Extreme Vascularity Complex
  • Includes the potent antioxidant Grape Seed Extract
  • Contains Nitrosigine and Citrulline Malate to act as nitric oxide precursors
  • Available in bottles containing 90 capsules and 180 capsules

Cellucor NO3 Chrome is an incredibly effective nitric oxide supplement that uses Arginine Nitrate as part of its Extreme Vascularity Complex to give you skin-splitting pumps every time you train.

With its range of nitric oxide precursors, antioxidants, and other performance-enhancing ingredients, Cellucor NO3 Chrome is easily the winner of this year’s Best Nitric Oxide Supplement Award.

 $49.99 (180 capsules)  Check Current Price

Wrapping Up

So by now you should have the information to easily figure out which nitric oxide supplement is going to be the best option for you.

As you can see there are a lot of different nitric oxide products on the market, some which incorporate additional ingredients like Creatine, Beta Alanine, and stimulants like Caffeine. If you are looking for a comprehensive pre-workout formula then this type of product definitely makes sense.

On the other hand, a more focused supplement might be your best bet if you’re purely looking for enhanced pumps.

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