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Best Lysine Supplements

10 Best Lysine Supplements for 2019

If you’re looking for the best lysine supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Lysine Supplements Guide.

Top 10 Lysine Supplements

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#1Now Foods L Lysine SNOW Foods L-LysineGet it on Amazon
#2Solgar L Lysine SSolgar L-LysineGet it on Amazon
#3Source Naturals L Lysine SSource Naturals L-LysineGet it on Amazon
#4Solaray L Lysine SSolaray L-LysineGet it on Amazon
#5Country Life L Lysine SCountry Life L-LysineGet it on Amazon
#6Spring Valley L Lysine SSpring Valley L-LysineGet it on Amazon
#7Pure Encapsulations L Lysine SPure Encapsulations L-LysineGet it on Amazon
#8Thorne Research L Lysine SThorne Research L-LysineGet it on Amazon
#9Superior Labs L Lysine SSuperior Labs L-LysineGet it on Amazon
#10Designs For Health L Lysine SDesigns For Health L-LysineGet it on Amazon

Lysine Supplements Guide

What is Lysine?

Lysine, scientific name diaminohexanoic acid or alpha-epsilon-diaminocaproic acid, is an essential amino acid, which means that the body requires it for daily function and maintenance. Lysine cannot be synthesized by the body’s metabolic processes so this amino acid must be obtained either through diet or through supplements.

Lysine was discovered in 1889 as a component of casein, which is a protein in milk. It’s commonly added to animal feed in order to insure adequate amounts in the human diet although some individuals may require supplemental lysine. Vegetarians can obtain lysine through supplements or through consumption of beans, cheese and other dairy products, eggs, lentils, nuts, soy, and seeds. Vegans may require supplements in order to obtain adequate amounts of lysine in their diet since they don’t consume dairy products or eggs.

After ingestion, lysine is transported by the blood stream to the liver, where it is then broken down, or catabolyzed, and released to other organs and systems of the body. Depending on the individual, this process can take from four to six hours to complete.

Lysine’s bio-availability from foods may be reduced by their preparation methods. Dry cooking at high heat, cooking in combination with fructose or glucose, or in combination with yeast and/or sucrose can all reduce the bio-availability of lysine in food.

Lysine is available in several forms, such as:

  • L-Lysine
  • Lysine HCl
  • Lysine acetylsalicylate
  • Lysine clonixinate
  • Lysine oxidase
  • Lysine succinate
  • Powder form


A dosage above nine grams, or 9000 mg, per day may cause stomach pain, nausea, or diarrhea. Some users have reported constipation when taking lysine. Others have indicated the presence of greasy stools, although that was associated with a high-fat diet, and a reduction in fat intake alleviated the problem.

Occasionally, elevated ketones will present in those who take a lysine supplement. Usually increasing water intake and reducing slightly the dosage of lysine has corrected the problem.

Lysine may be transmitted through breast milk, so lactating mothers should inform their medical professional if they are taking lysine supplements. When used in combination with iron and vitamin supplements, some pregnant women showed elevated hemoglobin levels. Pregnant women should inform their medical professionals if they are taking supplemental lysine.

Using calcium supplements in conjunction with lysine supplements may result in an elevated level of calcium in the body. Elevated aminoglycoside toxicity may also occur when taking supplemental lysine.

Arginine increases the proliferation of some virus cells, lysine is its antagonist, so taking lysine will decrease the level of arginine in the body.

One report of Fanconi syndrome, which is a rare disorder of kidney functions, and tubulointerstitial nephritis has been reported by a user who took lysine supplements for five years as a treatment for chronic viral infection. Other information, such as diet, overall health, other medications, and so forth, is not indicated.

Since lysine is absorbed slowly into the tissues, high doses are unlikely to cause deleterious side effects but should be discussed with a medical professional. Before giving lysine to a child, a medical professional should be consulted.

Always speak with a medical professional or doctor before taking any supplements. Always read the product label for instructions and directions.

Taking Lysine

As a supplement, lysine should be taken either with food or without but should not be taken in combination or conjunction with calcium supplements.

Those who have gall bladder issues or have liver or kidney disease should consult with a medical professional before taking lysine supplements.

What to Look for in a Good Lysine Supplement

A good lysine supplement will have no fillers. It should contain lysine HCl, or whatever other form the label indicates, and no other ingredients except as are contained in the capsule itself. It should not be made from soy or contain other allergens, such as wheat, gluten, egg, fish, shellfish, tree nuts, or any other common allergens.

Buy a reputable brand that is manufactured in the U.S. Other countries may have less stringent manufacturing processes and produce a product that may be impure. Be sure to buy pharmaceutical grade lysine. Some lysine tablets are large, so if ingestion is an issue, it might be advisable to purchase a greater quantity of smaller tablets.

Not all capsules are vegetarian. Those who are vegan or vegetarians should verify that the gelatin is indeed made without animal products or opt for tablets.

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