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Best Benfotiamine Supplements

10 Best Benfotiamine Supplements for 2019

If you’re looking for the best benfotiamine supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Benfotiamine Supplements Guide.

Top 10 Benfotiamine Supplements

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#1Doctor's Best Benfotiamine SDoctor’s Best BenfotiamineGet it on Amazon
#2Life Extension Mega Benfotiamine SLife Extension Mega BenfotiamineGet it on Amazon
#3Country Life Vitamin B1 With Benfotiamine SCountry Life Vitamin B1 with BenfotiamineGet it on Amazon
#4Source Naturals Benfotiamine SSource Naturals BenfotiamineGet it on Amazon
#5Douglas Laboratories Ultra Benfotiamine SDouglas Laboratories – Ultra BenfotiamineGet it on Amazon
#6Pure Encapsulations – Benfomax SPure Encapsulations – BenfoMaxGet it on Amazon
#7Swanson Maximum Potency Benfotiamine SSwanson Maximum-Potency BenfotiamineGet it on Amazon
#8Vitacost Nsi Benfotiamine SVitacost NSI BenfotiamineGet it on Amazon
#9Piping Rock Health Products Benfotiamine SPiping Rock Health Products BenfotiamineGet it on Amazon
#10Bestvite Benfotiamine SBestvite BenfotiamineGet it on Amazon

Benfotiamine Supplements Guide

What is Benfotiamine?

Benfotiamine is a chemical form of vitamin B1 that’s fat-soluble. Benfotiamine is actually found in foods as well, occurring naturally in well-known health foods like plants of the allium variety like onions and garlic.

Benfotiamine derives from the vitamin B-1 (thiamin) compound; although, it is a synthetic form. The FDA considers it a vitamin supplement under the Dietary Supplement Health and Education Act. Some foreign countries classify it as a drug.

Research supports it as a tolerable alternative to thiamine hydrochloride, despite both being safe. The lipid-soluble (fat-soluble) nature of benfotiamine allows for quicker absorption and for it to stay in the body longer. It is also available in a higher dosage than thiamine hydrochloride. However, it’s the fat-soluble factor that makes it better suited for both therapeutic and antioxidant use.

How is it Different than Naturally Occurring Thiamine?

Science has already explained how the body better absorbs fat-soluble vitamins, which increases its bioavailability. Naturally occurring thiamine is water-soluble, and the body only stores small amount. This leads to deficiency occurring in as little as 14 days.

Where did Benfotiamine Originate?

Created in Japan in the 50’s, benfotiamine is a synthetic vitamin. It is an S-acyl Vitamin B1 analogue, which means its structure is similar to that of a B-1 vitamin/thiamine. In addition, it shares other similarities to thiamine and B-1 vitamins, such as the lipid-soluble allithiamine present in the Allium family of plants like garlic and onions.

Before receiving its US patent, benfotiamine saw widespread use in Japan and Europe for several decades as a treatment option. Its original treatment was for alcoholic neuropathy (alcoholic neuritis), which many long-term alcoholics develop.

What Research Says About Benfotiamine

Research and studies provide a mixture of results. In a few studies, research noted no significant health changes to an overall disease. Some limitations to studies are the dose or length of time. This does not discount symptoms associated with diseases, such as pain related neuropathy or conditions that lead to its therapeutic benefits, and it does not ignore that a higher daily dose might achieve the study’s intended result.

Other positive benefits were conclusive in studies, even when the main theory was not met. A Norwegian study found high-doses of benfotiamine (up to 600mg/day) offered their short-term (3-12 weeks) Type-1 diabetic participants improved symptomatic scores in regards to diabetic polyneuropathy, even though the 300mg dose per day study offered no significant effects over 24 months to other Type-1 diabetic participants.

The most promising diabetic-related study to date shows a strong connection with taking benfotiamine in order to increase the creation of the enzyme transketolase. Transketolase reduces metabolite build up in hypoglycemia that damages small arteries, which can affect retinopathy, nephropathy, and neuropathy. The enzyme transketolase is a thiamine diphosphate that is typically reduced in diabetic patients. Increasing its amount displays promise in reversing some side effects, long and short term, associated with hypoglycemia, but further studies will determine whether this is a solid preventative measure for diabetic patients.

Most human and animal studies to date center only on diabetes and diabetic related complications, such as hypoglycemia and nerve damage. Few studies have been completed on other conditions; however, research does support its use as a pain receptor blocker and its use with rheumatoid arthritis patients, when used in conjunction with the enzyme Prostatic acid. Whether these benefits extend to other conditions requiring pain management is unknown. Another study showed a slight increase in Flow-Mediated Vasodilation (FMD) benefit to healthy smokers who took 350mg three times a day.

double-blind random study supports use in alcoholic patients who suffer from alcoholic neuropathy, which is what the supplement was originally intended to treat. In addition, since it is stored in the body’s fatty tissues and reacts similar to thiamine, it is also a viable option for anyone deficient or at risk of deficiency in thiamine.

Researchers have been considering and conducting longer-term studies as well as new studies that include benfotiamine and other B vitamins and supplements. Plans also includes testing and researching its effect on cognitive function and as a preventive measure for cognitive disease, such as Alzheimer’s and dementia.


Like most supplements, benfotiamine may cause health complications or medical interactions. While it’s always best to consult with your doctor, it’s known that this supplement may cause digestive problems or low blood pressure. Additionally, evidence is still lacking in estimating the most accurate dosing amount of benfotiamine for optimal health. There is also no established evidence regarding the safety of this supplement for pregnant or nursing women or for children.

Always speak with a medical professional or doctor before taking any supplements. Always read the product label for instructions and directions.

Taking Benfotiamine

Benfotiamine is available in capsule form. Some manufacturers also make a cream that can be applied to the skin. This type of cream should be applied to the affected area once or twice daily.

What to Look for in a Good Benfotiamine Supplement

Good supplements will tell you about their level of quality on the front of the product, and many are vegan or vegetarian as well. The product labels should also tell you what to expect from the supplement, including benefits.

Product descriptions should also make note of how bioavailable the products are. Be sure also to look for information like how many other ingredients are in the product and what they are.

You want to be sure that you are getting a maximum amount of benfotiamine and a minimum amount of fillers or other ingredients like cellulose or gelatin.

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