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Best Pqq Supplements

10 Best PQQ Supplements – Ranked & Reviewed for 2017

If you’re looking for the best PQQ supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Pyrroloquinoline Quinone Supplements Guide.

Top 10 Pyrroloquinoline Quinone Supplements

#1 Jarrow Formulas Pyrroloquinoline Quinone S Jarrow Formulas PQQ More Info
#2 Doctor's Best Pqq Nutritional Supplement S Doctor’s Best PQQ More Info
#3 Health Thru Nutrition Pqq 20mg S Health Thru Nutrition PQQ More Info
#4 Life Extension Pqq Caps With Biopqq S Life Extension PQQ More Info
#5 Now Foods Pqq Energy Plus S Now Foods PQQ Energy Plus More Info
#6 Swanson Pqq Pyrroloquinoline Quinone S Swanson PQQ More Info
#7 Relentless Improvement Pqq 20mg S Relentless Improvement PQQ More Info
#8 Absorb Health Pqq (pyrroloquinoline Quinone) S Absorb Health PQQ More Info
#9 Piping Rock Health Products Pqq 20 Mg S Piping Rock Health Products PQQ More Info
#10 Source Naturals Pqq Mind S Source Naturals PQQ Mind More Info

Pyrroloquinoline Quinone (PQQ) Supplements Guide


Pyrroloquinoline quinone, commonly known as PQQ or Methoxatin, is a powerful coenzyme that displays a wide range of antioxidizing, neuroprotective, and anti-aging properties. Though research is still in its early stages, scientists believe PQQ has the potential to play a vital role in the future of medicine.

Parsley, green peppers, kiwis and countless other plants contain trace amounts of Methoxatin. The problem is that even fermented soybeans – the world’s most PQQ-rich food – can’t provide a daily serving of it. To put things into perspective, there are 61 nanograms of the coenzyme in a gram of soybeans. That means you’d have to eat over 720 pounds of fermented soy per day to ingest the recommended 20mg dose of PQQ.

Fortunately, today pure Methoxatin is readily available in the form of PQQ supplements. Of course, in order to decide whether they’re right for your diet, you should learn all the facts and understand how these supplements work. That’s why this comprehensive guide details everything you need to know about PQQ.

What is PQQ?

Because pyrroloquinoline quinone is a relatively recent discovery, some of its secondary effects may still be undiscovered. That being said, PQQ’s two main properties are impossible to ignore. Over the past decade, these properties have been thoroughly studied and tested. Here’s what we now know about them:

#1. It’s an Incredibly Potent Antioxidant That Works On a Cellular Level.

Compounds necessary for proper protein activity in cells are called coenzymes. (Simply put, they help enzymes do their job.) In the human body, PQQ molecules act as redox coenzymes. The “redox” stands for oxidation-reduction, which implies a continuous cycle of antioxidation.
In other words, at first, PQQ breaks down during oxidation just like regular antioxidants. But then it gets recycled back into its original form and continues to revigorate the organism on a cellular level.

PQQ is also uniquely stable during this redox process. It is the only known coenzyme that goes through several thousand oxidation cycles before it leaves the body.

#2. It Stimulates Mitochondrial Function & Metabolism

Sometimes referred to as the engine cells run on, the mitochondria is where proteins, fats, sugars, and oxygen are metabolized into energy. And PQQ appears to stimulate mitochondrial growth at an unprecedented rate. Although some scientists are still skeptical about PQQ, a 2006 study showed that it improves both the production of mitochondria and their function (in rats).

In 2013, researchers were finally able to move on to human testing. After just one week-long trial, all participants displayed a rise in mitochondrial activity. Furthermore, an overwhelming majority of the test subjects also experienced a steep improvement of their inflammation indicators.

Benefits of PQQ Supplements

Most people who were blown away by the benefits of PQQ – including countless healthcare professionals and dieting experts – swear by them every day. Meanwhile, those who got fewer results than they expected claim the supplement is completely ineffective.

But every human body is a unique organism, and each one has different needs. It makes no sense to seek advice about your personal nutrition from someone else. As such this decision should be based solely on facts that are backed by science and tested in a controlled experiment.

Here are some of the proven benefits of PQQ supplements.

Increased Brain Function

As evidenced by one recently published study, PQQ can induce rapid Schwann cell regeneration. Schwann cells make up the most intricate parts of the central nervous system. One of the reasons why our memory and cognition deteriorates as we grow older is that the aging process slows down Schwann cell growth and eventually stops it. Therefore, methoxatin supplements can help you stay sharp as well as improve your memory function.

A similar experiment was conducted in 1993 by Japanese scientists. They demonstrated how the coenzyme can stimulate synthesis of NGF (Nerve Growth Factor), which is directly related to neural brain function. The potential implications of such research include curing brain damage victims and preventing Alzheimer’s. Unfortunately, there’s still no way to deliver PQQ directly into the brain.

Improved Sleep Quality & Mood

As a stimulant of mitochondrial function, PQQ significantly increases energy levels. Yet, since the energy boost is a result of a natural, healthy process, it also helps increase sleep quality. And, for obvious reasons, better sleep is the best catalyst for a positive mood.

In 2012, 17 adults with various sleep-impairing disorders volunteered for an open-label study focused on the effects of Methoxatin on long-term sleep quality. They were administered 20 milligrams of PQQ every day for a period of eight weeks. All 17 subjects showed some degree of improvement in both sleep quality and overall mood.

Decreased Levels of Free Radicals & Inflamation

Though the human body doesn’t produce PQQ, it wouldn’t be able to stay alive without trace amounts of the coenzyme. Free radicals, which are responsible for the aging process, are neutralized by antioxidants like Methoxatin. Coupled with the cognitive benefits, this supplement can help keep both your mind and body young.

Multiple studies concluded that PQQ reduces the concentration of free radicals by 45% within an average of three weeks. However, it seems that a decrease of inflammatory symptoms cannot be achieved if the daily dosage is set under 20mg.

Prevention of Arthritis

Though it has been vigorously studied for over a decade now, the coenzyme continues to demonstrate new benefits every year. For instance, a large-scale 2015 study yielded proof that PQQ can help prevent auto-immune disorders. Surprisingly enough, it works particularly well for osteoarthritis patients.

Heart Health Support

Recent animal studies support the theory that PQQ can be most effective as a cardiovascular supplement. Seconds before a heart attack happens, the heart cells become drained of oxygen and glucose, allowing inflammatory compounds to fill the void.
Well, it turns out PQQ can increase mitochondrial counts in any kind of cells. And the more mitochondria are active, the more oxygen and glucose is metabolized by the cells.

Are There Any Side Effects?

Though the supplement hasn’t caused adverse side effects in any of the human trials, some people may react differently than others. Once again, PQQ is a very powerful coenzyme and research is still in its relatively early stages.

In rare cases, people have reported these mild side effects:

  • headache
  • fatigue
  • drowsiness

How to Take PQQ Supplements

The majority of Methoxatin supplements come in capsules. Each capsule contains 10-20mg of pure PQQ. It’s best to start off on a light regiment, so use it every other day for a week or so. If you’re not developing any adverse effects, switch to a daily dose.

Dosage should depend on your goals but the rule of thumb is 20mg of PQQ for every 150 lbs you weigh. The only other thing to remember is that treating inflammatory symptoms requires a higher dosage.

That being said, you should never need to ingest more than 40mg per day. A toxic dose of Methoxatin is 60mg, but there’s no reason to take that much and the coenzyme isn’t any more effective in large amounts.

What to Look For in a Good PQQ Supplement

There’s really only one factor to consider when choosing a PQQ supplement brand – whether you should look for a synthetic or an extracted version. Keep in mind that there’s absolutely no difference when it comes to molecular structure, effectiveness or viability.

  • The first option is chemically synthesized in a lab, which might sound sketchy but is actually a guarantee that you’re getting a pure, clean product.
  • The other type is extracted from fermented bacteria. Ironically enough, this is also done inside a laboratory. The only real difference is the extra safety warning on most natural PQQ packages. For some reason, the extracted compound is “not intended for women who are trying to get pregnant and lactating women.”

If you always choose organic products out of principle, go for the extract. Otherwise, you should probably opt for a synthetic version.

Note: Always speak with your doctor before taking any supplements featured on this website. This article has not been written, reviewed or endorsed by a medical professional and may not be used to diagnose or treat any medical conditions.