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Best Serine Supplements

10 Best L-Serine Supplements – Ranked & Reviewed for 2017

If you’re looking for the best l-serine supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our L-Serine Supplements Guide.

Top 10 L-Serine Supplements

#1 Bulksupplements Pure L Serine Powder S BulkSupplements Pure L-Serine Powder More Info
#2 Doctor's Best Phosphatidyl Serine S Doctor’s Best Phosphatidyl Serine More Info
#3 Now Foods Soy Free Phosphatidyl Serine S Now Foods Soy-free Phosphatidyl Serine More Info
#4 Nature's Way Phosphatidyl Serine S Nature’s Way Phosphatidyl Serine More Info
#5 Swanson Ajipure L Serine S Swanson Ajipure L-Serine More Info
#6 Douglas Laboratories L Serine S Douglas Laboratories – L-Serine More Info
#7 Micro Ingredients Pure L Serine Powder S Micro Ingredients Pure L-Serine Powder More Info
#8 Montiff Pure L Serine S Montiff – Pure L-Serine More Info
#9 Olympian Labs Soy Free Phosphatidylserine Complex S Olympian Labs Soy Free Phosphatidylserine Complex More Info
#10 Relentless Improvement L Serine S Relentless Improvement L-Serine More Info

L-Serine Supplements Guide


Serine, which can be found in foods (such as eggs whites, spirulina, and lima beans), is a non-essential amino acid that our bodies make. Serine can be manufactured into supplements, generally referred to as L-serine and D-serine.

L-serine is made from other amino acids like glycine, and it gets converted into D-serine in the glial cells. These supplements have been used to treat a wide array of disorders and symptoms resulting from a lack of Serine production in the body, including depression, anxiety, Chronic Fatigue Syndrome, Fibromyalgia, and insomnia.

To better understand if these supplements might be beneficial for you to take, we will go over what these supplements are, how they work, their known benefits and negative side effects, how to take them, and what to look for when you are shopping around for a good Serine supplement.

What Are Serine Supplements?

Serine, which is composed of the amino acids threonine and glycine, is a non-essential amino acid that helps to build proteins in the brain. Serine is also used to help create the compound phosphatidylserine, which is used to make the myelin sheaths that form protective barriers around the body’s nerve cells. Additionally, serine helps to fight off infections since it is found in immunoglobins and antibodies. It is also an important component in the relaying of messages throughout the nervous system.

Serine supplements are becoming more readily available on the market and can be purchased online or at grocery stores and pharmacies. Since Chronic Fatigue Syndrome and Fibromyalgia are seemingly becoming more prevalently recognized and diagnosed medical conditions, those who are diagnosed with them are looking to Serine supplements for treatment.

Benefits of Serine Supplements

A lack of Serine in the body means that the body is not able to produce enough Tryptophan, a neurochemical responsible for mood stabilization. When our bodies do not make enough Tryptophan (as well as serotonin), we tend to experience symptoms of depression, anxiety, and even insomnia. Low levels of serine also seem to be a factor in illnesses such as Fibromyalgia and Chronic Fatigue Syndrome (CFIDS). Therefore, one of the biggest benefits of taking Serine supplements is that it is able to generate enough Tryptophan to stabilize our moods.

Serine supplements can also assist in the creation of Creatine, which helps the muscles grow and remain strong. It is also beneficial if you have a slow metabolism and need your metabolic process sped up. Those with depression, fibromyalgia, and Chronic Fatigue Syndrome tend to all suffer from a lack of Creatine and a slow metabolism, both of which can be linked back to a probable Serine deficiency.

Additionally, since a lack of Serine in the body can weaken your immune system, adding Serine supplements to your daily regimen can boost your immune system by getting Serine to help produce more antibodies and immunoglobins needed for warding off toxic invaders.

Serine supplements can also be helpful for people who are not getting enough Serine from their food. Eggs, spirulina, and lima beans are all rich in Serine. However, if you have an allergy or intolerance to some of these foods (for example, many people cannot eat eggs due to a sensitivity), taking Serine supplements might help you gain the Serine you need to stabilize your levels.

Are There any Side Effects?

As with any supplement that you buy, you should always speak with your doctor first about Serine before actually taking it. Your doctor can provide recommendations for brands if they feel that you would benefit from taking Serine. Women who are pregnant, looking to become pregnant, or who are breastfeeding should refrain from taking Serine, as should children under the age of 18 since it is currently unknown just what kind and how much of an impact Serine supplements can have on babies and children.

An overabundance of Serine in the human body can lead to toxicity in the nerve cells, so you will want to make sure you are not taking too elevated of a serine dosage. If you already have a sufficient Serine level in your body, there is no need to take these supplements. Taking them could actually worsen your health.

Other known side effects of Serine supplements include nausea, vomiting, diarrhea, constipation, frequent urination, and insomnia. Most of the reported side effects are mild in nature. Those who take it and have stopped tend to report that they ceased taking their Serine supplements because they were either causing side effects or were just ineffective. Overall, it appears that Serine supplements are safe for most people to take if they have a lack of Serine being produced in their bodies.

How to Take Serine Supplements

Serine supplement dosages are going to vary somewhat based on your doctor’s recommendations and the brand that you buy. There is powdered L-serine available on the market as well as capsule formulas. Generally speaking, a daily dosage of Serine is somewhere in the ballpark of 400 to 600 mg/kg per day, divided up into four to six doses (of 100 mg/kg each). Typically, people opt to take the 600 mg/kg daily dosage.

Regardless of whether you are taking capsules or a powdered Serine mix, make sure you follow the directions listed on the packaging and/or those given to you by your doctor. Capsules are generally recommended to be taken with food and water. Powdered mixes can be mixed with water or juice. These powdered mixes tend to not have any taste and are completely water soluble, so you will not encounter an unpleasant taste or after-taste.

If you are taking other medications and/or supplements, you should check with your doctor to make sure that they will not cause a negative drug interaction that could worsen symptoms or cause new issues to occur.

What to Look for in a Good Serine Supplement

While there are many types and brand of Serine supplements on the market to choose from, the most crucial factor you should be looking for when buying a good Serine supplement is purity of the product. Just how much Serine is really in your Serine supplement? What else is listed on the packaging’s ingredients list? Since users tend to report getting the best results from pure Serine supplements, your best bet might be to spend the extra money to buy a high-quality pure Serine powder.

Many supplements contain additives and fillers that sometimes include allergens like soy, so those with allergies should be aware of this. Also, vegans and vegetarians should steer clear of any capsule that uses gelatin since this is a non-vegetarian product used in many capsule packagings. Instead, vegans and vegetarians are encouraged to look for capsule supplements that are made from hydroxypropyl methylcellulose (HPMC), which is a vegetarian and vegan-friendly capsule packaging semisynthetic product.

You should also know that L-serine and D-serine work a little bit differently. Whereas L-serine targets symptoms of neuropathy, Chronic Fatigue Syndrome, and fibromyalgia, D-serine is geared more toward slowing down symptoms of cognitive decline. D-serine enhances the effects of the other compounds that are found in N-methyl-D-aspartate (NDMA) receptors, including glutamate. D-serine is being evaluated for its use in treating schizophrenia and cocaine addiction.

To conclude, Serine supplements are safe for most people with a lack of Serine production in their bodies to take. While the powdered, pure form seems to be best, there are plenty of capsule brands to choose from. As always, consult with your doctor before trying these supplements. However, if you are at your wit’s end trying to cope with painful and persistent symptoms of Chronic Fatigue or fibromyalgia, taking Serine supplements might be one of the best ways for you to reverse some of those unpleasant symptoms.

Note: Always speak with your doctor before taking any supplements featured on this website. This article has not been written, reviewed or endorsed by a medical professional and may not be used to diagnose or treat any medical conditions.