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Best Hesperidin Supplements

10 Best Hesperidin Supplements – Ranked & Reviewed for 2017

If you’re looking for the best hesperidin supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Hesperidin Supplements Guide.

Top 10 Hesperidin Supplements

#1 Doctors Best Hesperidin Methyl Chalcone S Doctor’s Best Hesperidin Methyl Chalcone More Info
#2 Swanson Premium Hesperidin S Swanson Premium Hesperidin More Info
#3 Thorne Research Hmc Hesperidin S Thorne Research – HMC Hesperidin More Info
#4 Swanson Ultra Diosvein Diosmin Hesperidin S Swanson Ultra DiosVein Diosmin/Hesperidin More Info
#5 Douglas Laboratories Hesperidin Methyl Chalcone S Douglas Laboratories – Hesperidin Methyl Chalcone More Info
#6 Earhnaturalsupplements Hesperidin S EarhNaturalSupplements Hesperidin More Info
#7 Jarrow Formulas Venous Optimizer S Jarrow Formulas Venous Optimizer More Info
#8 Serene Dew Supplements Hesperidin Diosmin S Serene Dew Supplements Hesperidin Diosmin More Info
#9 Naturetition Supplements Hesperidin S Naturetition Supplements Hesperidin More Info
#10 Vitacost Brand Diosmin And Hesperidin With Diosvein S Vitacost Brand Diosmin & Hesperidin with DiosVein More Info

Hesperidin Supplements Guide


Hesperidin is a molecule found in citrus fruit; its name comes from “hesperidium,” the Latin name for a citrus fruit. Along with similar plant flavonoid substances, it is sometimes referred to as vitamin P, but hesperedin is not actually a vitamin. Hesperidin does, however, promote the formation of vitamin C complex in the body. Vitamin C complex is needed for the immune system to function properly.

Supplements are not strictly necessary in order to get hesperidin in one’s diet. The body gets hesperidin from eating citrus fruits like oranges, grapefruit, kumquats, pomelo, tangerines, lemons, and limes. High concentrations of hesperidin are located in the membranes and peels of citrus fruits, and lesser amounts are also found in foods including the following:

  • Apricot
  • Bilberries
  • Broccoli
  • Buckwheat
  • Green peppers
  • Plums
  • Yellow peppers

Since people generally eat only the pulp of the citrus fruit and not the peel (with the exception of the kumquat, which is usually eaten whole), some may choose to use hesperidin supplements to get a concentrated amount of hesperidin.

What is a Hesperidin Supplement?

Herbal dietary supplements that include hesperidin might be labeled with the active ingredient bioflavonoid, citrus bioflavonoid, or hesperidin methyl chalcone. Bioflavonoids are the components in plants that give them their distinctive smells, tastes, and colors. In plants, these chemical compounds help give protection from fungi, insects, and microbes. Animal studies suggest that bioflavonoids may offer human bodies some protection from cardiovascular disease and certain types of cancer.

As a dietary supplement, hesperidin is used for the treatment of conditions related to blood flow in the circulatory system and lymphedema (a fluid retention condition that is sometimes a side effect of treatment for breast cancer). Blood vessel conditions that are sometimes treated with hesperidin supplements as a complementary or alternative medicine include hemorrhoids, varicose veins, and poor circulation.

Hesperidin supplements have also been used to reduce inflammation, blood sugar, and blood pressure. Some evidence for these and other health benefits exists, but more research is needed in trials using human subjects before some of these claims will meet rigorous standards for scientific and medical evidence.

Benefits of Hesperidin Supplements

Hesperidin supplements may fight the effects of damage to the liver and kidneys caused by oxidation. Oxidation damages kidney and liver cells after they are exposed to unstable molecules called free radicals. As a form of antioxidant, the bioflavonoids in hesperidin supplements can help reverse this damage.

Some research has also suggested that a alpha-glucosyl hesperidin supplement may help reduce the effects of rheumatoid arthritis. Those who participated in the study drank a beverage containing a hesperidin supplement mixed into a beverage for a period of 12 weeks. Hesperidin’s effect of reducing inflammation inside the body may be responsible for this.

According to nutritionist Ann Louise Gittleman, Ph.D., hesperidin supplements can also help reduce the bothersome symptoms of perimenopause, particularly hot flashes. Gittleman has stated that the effects of hesperidin supplements, including encouraging strengthening of the blood vessels and encouraging drainage of excess fluids through the lymph nodes, can lead to relief from hot flashes. Studies in animals suggest hesperidin supplements may also be able to help reduce bone loss (osteoporosis) in the same way that statin drugs do, by inhibiting the action of a liver enzyme that in turn leads to lower cholesterol in the blood.

Hesperidin in Combination with Other Supplements

A combination of hesperidin supplements with vitamin C and butcher’s broom has been shown to have some effect in treating the symptoms of chronic venous insufficiency (CVI). Taking the dietary supplement for a period of between two and six months seemed to improve the condition, as evidenced by lessening of the swelling caused by fluids leaking from the blood vessels (edema). However, the study also suggested that the prescription drug Venoruton seems to be even more effective in relieving the symptoms of CVI.

Research suggests taking hesperidin supplements that also contain diosmin, another bioflavonoid compound found in citrus fruits, can relieve the symptoms of anal hemorrhoids, including bleeding, itching, pain, and swelling. This same research also suggests that this supplement combination may also help prevent hemorrhoids from reoccurring. Other studies have suggested that diosmin combined with hesperin can be helpful in healing small venous stasis ulcers of the leg and lowering blood sugar levels.

Citrus Bioflavonoids: General Benefits

The benefits of citrus bioflavonoids in general are thought to include lowering cholesterol and triglyceride levels, protecting brain function, and improving endothelial function (the function of the lining of blood cells). A citrus bioflavonoid called naringin has been linked to lower levels of Alzheimer’s disease in some studies.

Hesperidin can cross the blood-brain barrier the same way that naringin can, but more research must be done in order to determine if hesperidin supplements could be a treatment effective in preventing Alzheimer’s disease.

Are There any Side Effects?

Citrus fruits have long been part of the human diet, so for most people, taking hesperidin supplements for up to six months at a time is thought to be safe. Hesperidin supplements are considered to be nontoxic, so overdose is unlikely. Supplements containing hesperidin and diosmin are thought to be safe for pregnant and breast-feeding women when taken by mouth.

Some of the possible side effects of hesperidin supplements have been reported as diarrhea, headache, nausea, and stomach pain. As with any other herbal dietary supplement, consumers should consult with a health care provider before starting any new supplement regimen. Possible interactions between hesperidin supplements and prescription drugs or other supplements are unknown, and more research is needed in this area.

Hesperidin supplements have been known to slow blood clotting. Those who have blood clotting disorders should not take hesperidin supplements, and the supplements should be discontinued two weeks before any scheduled surgery. People who are allergic to citrus fruits should not take hesperidin supplements. Those who already have low blood sugar or low blood pressure may want to avoid hesperidin supplements, since these supplements are thought to make these numbers drop even lower.

How to Take Hesperidin Supplements

Hesperin supplements are normally taken by mouth in capsules, tablets, or powders. For treatment of anal hemorrhoids, the effective dosage is thought to be 150 mg of hesperidin combined with 1,350 mg of diosmin twice a day for four days, followed by 100 mg of hesperidin and 900 mg of diosmin twice per day for the three days after that. To help prevent hemorrhoids from reoccurring, the dosage is 50 mg of hesperidin with 450 mg of diosmin twice per day for up to three months.

For using hesperidin supplements to treat venous stasis ulcers, the recommended dosage is 100 mg of hesperidin and 900 mg of diosmin per day. This combination supplement can be taken every day for up to two months.

What to Look for in a Good Hesperidin Supplement

Citrus fruits naturally contain fairly large quantities of hesperidin in their peels and much smaller amounts of diosmin. Diosmin can be made out of hesperidin through a manufacturing process in the laboratory. Supplements that claim to contain both hesperidin and diosmin should have larger amounts of diosmin added so that the concentration of diosmin is sufficient to have a clinical effect. Consumers can look for supplements that list the specific amounts of diosmin and hesperidin among their active ingredients.

To help find supplements that have been tested for safety and consistency, consumers can look for a seal of approval from one of three consumer laboratories that test these products. NSF International, U.S. Pharmacopeia, and ConsumerLab.com are three third-party organizations that test dietary supplements to make sure they contain the active ingredients in the amounts reported on the packaging.

Note: Always speak with your doctor before taking any supplements featured on this website. This article has not been written, reviewed or endorsed by a medical professional and may not be used to diagnose or treat any medical conditions.