Home / Amino Acids / 10 Best Agmatine Supplements – Reviewed & Ranked for 2017
best-Agmatine-supplements

10 Best Agmatine Supplements – Reviewed & Ranked for 2017

If you’re looking for the best agmatine supplements to buy this year, then you’ve come to the right place

You can also get more info by jumping to our Agmatine Supplements Guide.

Top 10 Agmatine Supplements

#1 transparent-labs-rawseries-agmatine-s Transparent Labs RawSeries Agmatine More Info
#2 Nutricost-Agmatine-s Nutricost Agmatine More Info
#3 BulkSupplements-Pure-Agmatine-Sulfate-Powder-s BulkSupplements Pure Agmatine Sulfate Powder More Info
#4 GAT-Agmatine-s GAT Agmatine More Info
#5 Hard-Rhino-Agmatine-Sulfate-Powder-s Hard Rhino Agmatine Sulfate Powder More Info
#6 Primaforce-Agmatine-Powder-s Primaforce Agmatine Powder More Info
#7 Infinite-Labs-Agmatine-Booster-s Infinite Labs Agmatine Booster More Info
#8 Serious-Nutrition-Agmatine-s Serious Nutrition Agmatine More Info
#9 Olympian-Labs-Agmatine-Sulfate-s Olympian Labs Agmatine Sulfate More Info
#10 AI-Sports-Agmatine-s AI Sports Agmatine More Info

Agmatine Supplements Guide


Although agmatine was discovered in the early 1900’s, it is still not a well known substance yet. The reason for this is that most of the studies pertaining to it have only been done on animals. But very little of the research has been tried out on a group of humans. Still, the animals in the experiments had a similar DNA sequence as humans, so a lot of the information can be used as far as what effect that it has on the body.

It has become crucial that people learn the facts regarding what agmatine can do because supplements containing the substance have already been put out on the market despite the lack of research that is available. So this article will discuss some of the most important aspects of this product for those who are interested in trying it.

What is Agmatine?

Agmatine is also called “decarboxylated arginine” because it is derived from the amino acid L-arginine. The carboxylic acid in the L-arginine is removed, which creates a whole new molecule. It acts as a unique neurotransmitter that is unlike anything that most people have ever heard of. However, it naturally occurs in minute amounts in the brain in response to natural chemical reactions. For instance, when androgenic receptors need a ligand to connect them to other cells in the brain, they might use agmatine that has been synthesized for this process.

When it is taken, it can’t pass through cell membranes on its own. It has to have a transporter. The reason for this is its two positive charges. Usually, there is both a positive and negative charge available to make the transition easier.

L-arginine is found in small amounts in common foods that are high in amino acids, such as beef, fish, and dark chocolate. But the body can’t convert L-arginine to agmatine in high enough quantities on its own. That is why it has to be taken separately in a supplement.

Benefits of Agmatine

This remarkable substance is the most beneficial to adults. It isn’t recommended for children because no one knows how it could affect their brain chemistry on a long-term basis. There has been in vitro studies done that suggests it doesn’t pass from a mother to her baby still in the womb though. And it hasn’t been found in breast milk in mothers that take it either. However, most adults shouldn’t use agmatine for more than a few weeks at a time just to be safe though. Some of the benefits of agmatine include:

Pain Relief

Agmatine increases the effects of strong painkillers, such as morphine and fentanyl. Researchers believe that this is due to the way that it acts as an agonist towards the isomer 2-imidazoline and androgenic receptors that are found in the brain. So it can be helpful for cancer patients and others who have severe pain that isn’t being relieved by anything else. However, agmatine can’t be taken alone for this purpose because it will increase the perception of pain when no other medications are in the body. It has to work together with the morphine or fentanyl in a synergistic way. And it only helps dull the pain. So it shouldn’t be thought of as a complete cure for any medical condition.

Nootropic Potential

Studies that were done that intentionally tried to induce memory loss and confusion in the brain while an animal was taking agmatine found that it offers protective effects. In fact, it helped improve cognitive abilities. So now, it is being called a “nootropic,” which means that it improves the processes of the brain. Memory recall, thinking, and the ability to learn are all intensified. And it also helps the mind handle stress and anxiety from situations that would normally induce a fear-based response. Because of this, agmatine may be beneficial to patients suffering from dementia. This supplement isn’t dose dependent though. The amount of it that is taken doesn’t correlate to the benefits. So “super loading” on agmatine isn’t recommended.

Are There Any Side Effects?

Luckily, there are very few side effects to agmatine. If it is taken in large doses, some people experience nausea and diarrhea that is significant enough to make them stop using it. The symptoms subside when the substance leaves the body though. And alcoholics who take it to relieve their symptoms of withdrawal often develop serious stomach ulcers from it, which have to be treated separately once the agmatine is out of their body.

There hasn’t been any signs of agmatine becoming addictive, but if it is used inappropriately with other illicit drugs to increase their effectiveness, there is a chance that someone could become very sick or even die from the reaction. The body isn’t capable of handling the stress from agmatine both blocking and increasing the effects of drugs simultaneously. It is the most dangerous if a person tries to use more than one illicit substance at the same time, such as drugs and alcohol. Several types of prescription medications shouldn’t be mixed with it either.

Agmatine also increases the appetite. But this isn’t necessarily a bad side effect. Those who are struggling to get enough calories each day because they don’t feel hungry can benefit from it. However, it should be noted that the cravings are usually for carbohydrates after a person has already had a meal. So obese people trying to lose weight might end up gaining more from the extra calories. The craving for carbohydrates may be related to the way that this supplement decreases and stabilizes high sugar levels in the body.

How to Take Agmatine

Agmatine works the best when it is received in an injection. But this method of transmission in the body isn’t practical. Too few people are interested in having several shots a day just to get its benefits. So an over-the-counter powdered version has become available. People can now scoop it into a smoothie or down a few capsules of it before their workout.

However, it should be mentioned that protein blocks the effects of agmatine. So it shouldn’t be taken with a meal that contains meat. Athletes who use whey powder to increase their protein intake should wait several hours before they take agmatine. It is helpful to take it first thing in the morning because it boosts energy some.

The recommended dose for agmatine is about 2,670 milligrams a day. But this amount may need to be decreased a little for someone who is small in stature. People who are exceptionally tall may want to ask their doctor what dose they should take. To prevent an overdose, it helps to start out with a lower dose of the product. Then, slowly increase the amount until the full 2,670 milligram dose is in the body.

Some agmatine supplements and powders are supposed to be taken about three times a day. Their individual doses range from 250 to 1,000 milligrams for each pill or scoop of powder though. But they should never exceed this total amount.

What to Look for in a Good Agmatine Supplement

Agmatine isn’t a substance that should be used frivolously by those who want to prepare for an exam or focus on a task. But still, many people may try to sell college students or other young people unlabeled pills or powder that they claim contains agmatine. This is very dangerous though because there is no guarantee on what is really in it. And only those who are over the age of 21-years-old should use it after they consult with their doctor about any adverse reactions that they could have with any of their other medications. With that in mind, there are some important aspects of a good agmatine supplement that should be noted.

First of all, this supplement should only be purchased in person at a reputable health food store unless the company that it is sold through over the internet is a trusted source. If a person isn’t sure about the company, then they can try doing a little research over the internet to check for any complaints or scams that they have been involved with. Or they can call the Better Business Bureau for more information about how long the company has been in business and whether or not they are really legitimate.

Next, it helps to buy an agmatine supplement that has a money-back guarantee. Companies that offer this type of warranty are usually more reputable. Since they don’t want to lose money, they also tend to sell better quality products.

And only buy this product if it is the only ingredient in the supplement. It is usually listed as “agmatine sulfate” on the label. Sometimes, companies include it as part of a formula that they claim will improve brain and workout performance. But there is no guarantee if all of the ingredients in the bottle will work with a person’s body and brain chemistry though. There is also an increased risk for the formula contradicting the effects of other pharmaceutical medications that someone takes.

Note: Always speak with your doctor before taking any supplements featured on this website. This article has not been written, reviewed or endorsed by a medical professional and may not be used to diagnose or treat any medical conditions.